Development of a Novel Electrochemiluminescence ELISA for Quantification of α-Synuclein Phosphorylated at Ser129 in Biological Samples
Synucleinopathies are a group of neurodegenerative diseases including Parkinson's
disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). These …
disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). These …
[HTML][HTML] Aggregate-prone brain regions in Parkinson's disease are rich in unique N-terminus α-synuclein conformers with high proteolysis susceptibility
JA Wiseman, HC Murray, RLMF Faull… - npj Parkinson's …, 2024 - nature.com
In Parkinson's disease (PD), and other α-synucleinopathies, α-synuclein (α-Syn) aggregates
form a myriad of conformational and truncational variants. Most antibodies used to detect …
form a myriad of conformational and truncational variants. Most antibodies used to detect …
Deep learning-assisted single-molecule detection of protein post-translational modifications with a biological nanopore
Protein post-translational modifications (PTMs) play a crucial role in countless biological
processes, profoundly modulating protein properties on both spatial and temporal scales …
processes, profoundly modulating protein properties on both spatial and temporal scales …
[HTML][HTML] Carboxyl truncation of α-synuclein occurs early and is influenced by human APOE genotype in transgenic mouse models of α-synuclein pathogenesis
GM Lloyd, B Long, S Quintin, ZA Sorrentino… - Acta neuropathologica …, 2023 - Springer
Post-translational modifications to the carboxyl (C) terminus domain of α-synuclein can play
an important role in promoting the pathologic aggregation of α-synuclein. Various cleavages …
an important role in promoting the pathologic aggregation of α-synuclein. Various cleavages …
[HTML][HTML] Therapeutic Implications and Regulations of Protein Post-translational Modifications in Parkinsons Disease
T Mishra, S Singh, TG Singh - Cellular and Molecular Neurobiology, 2024 - Springer
Parkinsons disease (PD) is a neurodegenerative disorder characterized by dopaminergic
neuron loss and alpha-synuclein aggregation. This comprehensive review examines the …
neuron loss and alpha-synuclein aggregation. This comprehensive review examines the …
[HTML][HTML] Distribution of phosphorylated alpha-synuclein in non-diseased brain implicates olfactory bulb mitral cells in synucleinopathy pathogenesis
Synucleinopathies are neurodegenerative diseases characterized by pathological
inclusions called “Lewy pathology”(LP) that consist of aggregated alpha-synuclein …
inclusions called “Lewy pathology”(LP) that consist of aggregated alpha-synuclein …
[HTML][HTML] A 14-day pulse of PLX5622 modifies α-synucleinopathy in preformed fibril-infused aged mice of both sexes
TN Bhatia, AS Jamenis, M Abbas, RN Clark… - Neurobiology of …, 2023 - Elsevier
Reactive microglia are observed with aging and in Lewy body disorders, including within the
olfactory bulb of men with Parkinson's disease. However, the functional impact of microglia …
olfactory bulb of men with Parkinson's disease. However, the functional impact of microglia …
[HTML][HTML] Development and validation of an expanded antibody toolset that captures alpha-synuclein pathological diversity in Lewy body diseases
The abnormal aggregation and accumulation of alpha-synuclein (aSyn) in the brain is a
defining hallmark of synucleinopathies. Various aSyn conformations and post-translationally …
defining hallmark of synucleinopathies. Various aSyn conformations and post-translationally …
[HTML][HTML] Specific detection of physiological S129 phosphorylated α-Synuclein in tissue using proximity ligation assay
R Arlinghaus, M Iba, E Masliah… - Journal of …, 2023 - content.iospress.com
Background: Synucleinopathies are a group of neurodegenerative disorders that are
pathologically characterized by intracellular aggregates called Lewy bodies. Lewy bodies …
pathologically characterized by intracellular aggregates called Lewy bodies. Lewy bodies …
The Interaction Between Nutraceuticals and Gut Microbiota: a Novel Therapeutic Approach to Prevent and Treatment Parkinson's Disease
L Yao, Y Yang, X Yang, MJ Rezaei - Molecular Neurobiology, 2024 - Springer
Parkinson's disease (PD) is a complex neurodegenerative disorder characterized by the
progressive loss of dopaminergic neurons, leading to motor and non-motor symptoms …
progressive loss of dopaminergic neurons, leading to motor and non-motor symptoms …