Synucleinopathies are a group of neurodegenerative diseases including Parkinson's
disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). These …

In Parkinson's disease (PD), and other α-synucleinopathies, α-synuclein (α-Syn) aggregates
form a myriad of conformational and truncational variants. Most antibodies used to detect …

Protein post-translational modifications (PTMs) play a crucial role in countless biological
processes, profoundly modulating protein properties on both spatial and temporal scales …

Post-translational modifications to the carboxyl (C) terminus domain of α-synuclein can play
an important role in promoting the pathologic aggregation of α-synuclein. Various cleavages …

Parkinsons disease (PD) is a neurodegenerative disorder characterized by dopaminergic
neuron loss and alpha-synuclein aggregation. This comprehensive review examines the …

Synucleinopathies are neurodegenerative diseases characterized by pathological
inclusions called “Lewy pathology”(LP) that consist of aggregated alpha-synuclein …

Reactive microglia are observed with aging and in Lewy body disorders, including within the
olfactory bulb of men with Parkinson's disease. However, the functional impact of microglia …

The abnormal aggregation and accumulation of alpha-synuclein (aSyn) in the brain is a
defining hallmark of synucleinopathies. Various aSyn conformations and post-translationally …

Background: Synucleinopathies are a group of neurodegenerative disorders that are
pathologically characterized by intracellular aggregates called Lewy bodies. Lewy bodies …

Parkinson's disease (PD) is a complex neurodegenerative disorder characterized by the
progressive loss of dopaminergic neurons, leading to motor and non-motor symptoms …