Caenorhabditis elegans survives on ephemeral food sources in the wild, and the species
has a variety of adaptive responses to starvation. These features of its life history make the …

The T arget of R apamycin (TOR or mTOR) is a serine/threonine kinase that regulates
growth, development, and behaviors by modulating protein synthesis, autophagy, and …

Zinc is a critical component in a number of conserved processes that regulate female germ
cell growth, fertility, and pregnancy. During follicle development, a sufficient intracellular …

Insulin signaling regulates various aspects of physiology, such as glucose homeostasis and
aging, and is a key determinant of female reproduction in metazoans. That insulin signaling …

Kinase translocation reporters (KTRs) are genetically encoded fluorescent activity sensors
that convert kinase activity into a nucleocytoplasmic shuttling equilibrium for visualizing …

Stem cell systems regulate tissue development and maintenance. The germline stem cell
system is essential for animal reproduction, controlling both the timing and number of …

High-content screening for gene profiling has generally been limited to single cells. Here,
we explore an alternative approach—profiling gene function by analyzing effects of gene …

Production of functional eggs requires meiosis to be coordinated with developmental
signals. Oocytes arrest in prophase I to permit oocyte differentiation, and in most animals, a …

The C. elegans germline provides an excellent model for analyzing the regulation of stem
cell activity and the decision to differentiate and undergo meiotic development. The distal …

The responses of different organs are important for organisms against the toxicity of
environmental toxicants. So far, the neuronal response to nanoplastic exposure and the …