Roles and drug development of METTL3 (methyltransferase-like 3) in anti-tumor therapy
P Xu, R Ge - European journal of medicinal chemistry, 2022 - Elsevier
Methyltransferase complex, such as METTL3/METTL14/WTP, catalyze N 6-methyladenosine
(m 6 A), which is the most abundant mRNA modification in mammals. Besides acting as am …
(m 6 A), which is the most abundant mRNA modification in mammals. Besides acting as am …
Zinc in cognitive impairment and aging
R Sun, J Wang, J Feng, B Cao - Biomolecules, 2022 - mdpi.com
Zinc, an essential micronutrient for life, was first discovered in 1869 and later found to be
indispensable for the normal development of plants and for the normal growth of rats and …
indispensable for the normal development of plants and for the normal growth of rats and …
Solution structure of the RNA recognition domain of METTL3-METTL14 N6-methyladenosine methyltransferase
Abstract N6-methyladenosine (m6A), a ubiquitous RNA modification, is installed by METTL3-
METTL14 complex. The structure of the heterodimeric complex between the …
METTL14 complex. The structure of the heterodimeric complex between the …
Structure of the zinc-finger antiviral protein in complex with RNA reveals a mechanism for selective targeting of CG-rich viral sequences
JL Meagher, M Takata… - Proceedings of the …, 2019 - National Acad Sciences
Infection of animal cells by numerous viruses is detected and countered by a variety of
means, including recognition of nonself nucleic acids. The zinc finger antiviral protein (ZAP) …
means, including recognition of nonself nucleic acids. The zinc finger antiviral protein (ZAP) …
Structure and RNA-binding of the helically extended Roquin CCCH-type zinc finger
JN Tants, L Oberstrass, JE Weigand… - Nucleic Acids …, 2024 - academic.oup.com
Zinc finger (ZnF) domains appear in a pool of structural contexts and despite their small size
achieve varying target specificities, covering single-stranded and double-stranded DNA and …
achieve varying target specificities, covering single-stranded and double-stranded DNA and …
The human CCHC-type zinc finger nucleic acid-binding protein binds G-rich elements in target mRNA coding sequences and promotes translation
The CCHC-type zinc finger nucleic acid-binding protein (CNBP/ZNF9) is conserved in
eukaryotes and is essential for embryonic development in mammals. It has been implicated …
eukaryotes and is essential for embryonic development in mammals. It has been implicated …
Understanding species-specific and conserved RNA-protein interactions in vivo and in vitro
While evolution is often considered from a DNA-and protein-centric view, RNA-based
regulation can also impact gene expression and protein sequences. Here we examine …
regulation can also impact gene expression and protein sequences. Here we examine …
Metabolic labeling based methylome profiling enables functional dissection of histidine methylation in C3H1 zinc fingers
Protein methylation is a functionally important post-translational modification that occurs on
diverse amino acid residues. The current proteomics approaches are inefficient to discover …
diverse amino acid residues. The current proteomics approaches are inefficient to discover …
RNAcompete methodology and application to determine sequence preferences of unconventional RNA-binding proteins
RNA-binding proteins (RBPs) participate in diverse cellular processes and have important
roles in human development and disease. The human genome, and that of many other …
roles in human development and disease. The human genome, and that of many other …