Exploration of protein function and interaction is critical for discovering links among
genomics, proteomics, and disease state; yet, the immense complexity of proteomics found …

Stretches of cytosine-rich DNA are capable of adopting a dynamic secondary structure, the i-
motif. When within promoter regions, the i-motif has the potential to act as a molecular switch …

The transcription factor Max is a basic-helix-loop-helix leucine zipper (bHLHLZ) protein that
forms homodimers or interacts with other bHLHLZ proteins, including Myc and Mxd proteins …

Castration-resistant prostate cancers (CRPCs) lose sensitivity to androgen-deprivation
therapies but frequently remain dependent on oncogenic transcription driven by the …

Transcription factors with aberrant activity in disease are promising yet untested targets for
therapeutic development, particularly in oncology. Directly inhibiting or activating the …

Increased understanding of intrinsically disordered proteins (IDPs) and protein regions has
revolutionized our view of the relationship between protein structure and function. Data now …

We previously described a mouse model of ulcerative colitis linked to T-bet deficiency in the
innate immune system. Here, we report that the majority of T-bet−/− RAG2−/− ulcerative …

Perfluorinated compounds (PFCs) and their short-chain derivatives are contaminants found
globally. Adsorption research on volatile perfluorinated compounds (VPFCs), which are the …

Fragment-based lead discovery has proven to be a powerful method in the drug discovery
process. The combinatorial output that is accessible by combining fragments is very …

The amyloid-β (Aβ) aggregation pathway is a key target in efforts to discover therapeutics
that prevent or delay the onset of Alzheimer's disease. Efforts at rational drug design …