HaloTag technology: a versatile platform for biomedical applications
Exploration of protein function and interaction is critical for discovering links among
genomics, proteomics, and disease state; yet, the immense complexity of proteomics found …
genomics, proteomics, and disease state; yet, the immense complexity of proteomics found …
[HTML][HTML] The i-motif as a molecular target: more than a complementary DNA secondary structure
SL Brown, S Kendrick - Pharmaceuticals, 2021 - mdpi.com
Stretches of cytosine-rich DNA are capable of adopting a dynamic secondary structure, the i-
motif. When within promoter regions, the i-motif has the potential to act as a molecular switch …
motif. When within promoter regions, the i-motif has the potential to act as a molecular switch …
[HTML][HTML] Stabilization of the Max homodimer with a small molecule attenuates Myc-driven transcription
NB Struntz, A Chen, A Deutzmann, RM Wilson… - Cell chemical …, 2019 - cell.com
The transcription factor Max is a basic-helix-loop-helix leucine zipper (bHLHLZ) protein that
forms homodimers or interacts with other bHLHLZ proteins, including Myc and Mxd proteins …
forms homodimers or interacts with other bHLHLZ proteins, including Myc and Mxd proteins …
[HTML][HTML] Modulating androgen receptor-driven transcription in prostate cancer with selective CDK9 inhibitors
Castration-resistant prostate cancers (CRPCs) lose sensitivity to androgen-deprivation
therapies but frequently remain dependent on oncogenic transcription driven by the …
therapies but frequently remain dependent on oncogenic transcription driven by the …
A complex task? Direct modulation of transcription factors with small molecules
AN Koehler - Current opinion in chemical biology, 2010 - Elsevier
Transcription factors with aberrant activity in disease are promising yet untested targets for
therapeutic development, particularly in oncology. Directly inhibiting or activating the …
therapeutic development, particularly in oncology. Directly inhibiting or activating the …
Targeting intrinsically disordered transcription factors: changing the paradigm
Increased understanding of intrinsically disordered proteins (IDPs) and protein regions has
revolutionized our view of the relationship between protein structure and function. Data now …
revolutionized our view of the relationship between protein structure and function. Data now …
[HTML][HTML] Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells
WS Garrett, S Punit, CA Gallini, M Michaud, D Zhang… - Cancer cell, 2009 - cell.com
We previously described a mouse model of ulcerative colitis linked to T-bet deficiency in the
innate immune system. Here, we report that the majority of T-bet−/− RAG2−/− ulcerative …
innate immune system. Here, we report that the majority of T-bet−/− RAG2−/− ulcerative …
[HTML][HTML] Fluorine-tailed glass fibers for adsorption of volatile perfluorinated compounds via FF interaction
Y Song, Y Wu, D Wu, X Ma, S Jiang, Z Peng… - Environment …, 2023 - Elsevier
Perfluorinated compounds (PFCs) and their short-chain derivatives are contaminants found
globally. Adsorption research on volatile perfluorinated compounds (VPFCs), which are the …
globally. Adsorption research on volatile perfluorinated compounds (VPFCs), which are the …
[HTML][HTML] DNA display of fragment pairs as a tool for the discovery of novel biologically active small molecules
JP Daguer, C Zambaldo, M Ciobanu, P Morieux… - Chemical …, 2015 - pubs.rsc.org
Fragment-based lead discovery has proven to be a powerful method in the drug discovery
process. The combinatorial output that is accessible by combining fragments is very …
process. The combinatorial output that is accessible by combining fragments is very …
Small molecule microarrays enable the discovery of compounds that bind the Alzheimer's Aβ peptide and reduce its cytotoxicity
J Chen, AH Armstrong, AN Koehler… - Journal of the American …, 2010 - ACS Publications
The amyloid-β (Aβ) aggregation pathway is a key target in efforts to discover therapeutics
that prevent or delay the onset of Alzheimer's disease. Efforts at rational drug design …
that prevent or delay the onset of Alzheimer's disease. Efforts at rational drug design …