Emerging activators and regulators of inflammasomes and pyroptosis
The inflammasome is a cytosolic immune signaling complex that induces inflammation and
pyroptosis. Inflammasome complexes respond to a variety of pathogens, as well as danger …
pyroptosis. Inflammasome complexes respond to a variety of pathogens, as well as danger …
The machineries, regulation and cellular functions of mitochondrial calcium
Abstract Calcium ions (Ca2+) are some of the most versatile signalling molecules, and they
have many physiological functions, prominently including muscle contraction, neuronal …
have many physiological functions, prominently including muscle contraction, neuronal …
Mitochondrial and endoplasmic reticulum calcium homeostasis and cell death
The endoplasmic reticulum (ER) and mitochondria cannot be considered as static structures,
as they intimately communicate, forming very dynamic platforms termed mitochondria …
as they intimately communicate, forming very dynamic platforms termed mitochondria …
The role of mitochondria in inflammation: from cancer to neurodegenerative disorders
The main features that are commonly attributed to mitochondria consist of the regulation of
cell proliferation, ATP generation, cell death and metabolism. However, recent scientific …
cell proliferation, ATP generation, cell death and metabolism. However, recent scientific …
Mitochondria and reactive oxygen species in aging and age-related diseases
Aging has been linked to several degenerative processes that, through the accumulation of
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure …
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure …
Mitochondria-associated membranes (MAMs) and inflammation
The endoplasmic reticulum (ER) and mitochondria are tightly associated with very dynamic
platforms termed mitochondria-associated membranes (MAMs). MAMs provide an excellent …
platforms termed mitochondria-associated membranes (MAMs). MAMs provide an excellent …
The molecular era of the mitochondrial calcium uniporter
The mitochondrial calcium uniporter is an evolutionarily conserved calcium channel, and its
biophysical properties and relevance to cell death, bioenergetics and signalling have been …
biophysical properties and relevance to cell death, bioenergetics and signalling have been …
Calcium dynamics as a machine for decoding signals
Calcium (Ca 2+) is considered one of the most-important biological cations, because it is
implicated in cell physiopathology and cell fate through a finely tuned signaling system. In …
implicated in cell physiopathology and cell fate through a finely tuned signaling system. In …
Mitochondria in lung disease
SM Cloonan, AMK Choi - The Journal of clinical …, 2016 - Am Soc Clin Investig
Mitochondria are a distinguishing feature of eukaryotic cells. Best known for their critical
function in energy production via oxidative phosphorylation (OXPHOS), mitochondria are …
function in energy production via oxidative phosphorylation (OXPHOS), mitochondria are …
Chronic stress weakens connectivity in the prefrontal cortex: architectural and molecular changes
E Woo, LH Sansing, AFT Arnsten, D Datta - Chronic Stress, 2021 - journals.sagepub.com
Chronic exposure to uncontrollable stress causes loss of spines and dendrites in the
prefrontal cortex (PFC), a recently evolved brain region that provides top-down regulation of …
prefrontal cortex (PFC), a recently evolved brain region that provides top-down regulation of …