Receptor Guanylyl Cyclase C (GC-C) was initially characterized as an important regulator of
intestinal fluid and ion homeostasis. Recent findings demonstrate that GC-C is also causally …

Colorectal cancer remains a major cause of mortality in the USA, despite advances in
prevention and screening. Existing therapies focus primarily on generic treatment such as …

Despite recent developments in therapy for inflammatory bowel diseases (IBDs), there have
been limited advances in diagnostic tools available to aid in disease management. A …

The aim of our case-control study was to identify novel biomarkers of Crohn's disease (CD)
that hold the potential to be employed in both disease diagnosis and monitoring activity. In …

Background and objectives Circulating proteins are integral to many biological processes.
We aimed to assess differences in the plasma proteome between people of different dietary …

LinaclotideisanewtypeofguanylatecyclaseC…, anintestinalsecretagogue. Itcan increasethelevelofcyclicguanosinephospha…
, therebyincreasingintestinalsecretionandpati…' pain threshold. Linaclotideiscurrentlyclinicallyapprovedfort …

The intestinal peptide hormones guanylin (GN) and uroguanylin (UGN) interact with the
epithelial cell receptor guanylate cyclase C to regulate fluid homeostasis. Some …