Oxidative phosphorylation is a source of energy production by which many cells satisfy their
energy requirements. Endogenous reactive oxygen species (ROS) are by-products of …

The human dopamine transporter gene SLC6A3 has been consistently implicated in several
neuropsychiatric diseases but the disease mechanism remains elusive. In this risk synthesis …

Parkinson disease (PD) is a complex heterogeneous neurodegenerative disorder.
Association studies have revealed numerous genetic risk loci and variants, and about 5 …

Objective The objective of this study was to identify clinical predictors of motor complications
(dyskinesia and motor fluctuations) of levodopa in a prospectively recruited PD cohort using …

L-dopa–induced dyskinesias (LID) is a common motor side effect of levodopa therapy of
Parkinson's disease (PD). The identified predictors may only partially account for the risk of …

The postsynaptic density (PSD) is a complex subcellular domain important for postsynaptic
signaling, function, and plasticity. The PSD is present at excitatory synapses and specialized …

Despite numerous studies on major depressive disorder (MDD) susceptibility, the precise
underlying molecular mechanism has not been elucidated which restricts the development …

Impact of Parkinson’s disease on the efficiency of masticatory cycles: Electromyographic
analysis - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage …

Background A good response to levodopa is a key feature of Parkinson's disease (PD), and
a poor response suggests an alternative diagnosis, but the extent of variation in the …

Due to the marked interpersonal neuropathologic and clinical heterogeneity of Parkinson's
disease (PD), current interventions are not personalized and fail to benefit all patients …