Cytochrome P450 enzymes (P450s) are broadly distributed among living organisms and
play crucial roles in natural product biosynthesis, degradation of xenobiotics, steroid …

The advent of modern C–H functionalization chemistries has enabled medicinal chemists to
consider a synthetic strategy, late stage functionalization (LSF), which utilizes the C–H …

Oxidation chemistry using enzymes is approaching maturity and practical applicability in
organic synthesis. Oxidoreductases (enzymes catalysing redox reactions) enable chemists …

C− H functionalization represents a paradigm shift from the standard logic of organic
synthesis. Instead of focusing on orchestration of selective reactions at functional groups, the …

Catalytic C–H oxyfunctionalization reactions have garnered significant attention in recent
years with their ability to streamline synthetic routes toward complex molecules …

Direct C–H bond functionalization catalyzed by non-precious transition metals is an
attractive strategy in synthetic chemistry. Compared with the precious metals rhodium …

Cytochromes P450 (P450 or CYP) are heme-containing enzymes that catalyze the
introduction of one atom of molecular oxygen into nonactivated C–H bonds, often in a regio …

Plants possess myriads of secondary metabolites with a broad spectrum of health-promoting
benefits. To date, plant extraction is still the primary route to produce high-value natural …

C–H functionalization is a very active research field that has attracted the interest of
scientists from many disciplines. This Outlook describes the collaborative efforts within the …

Covering: up to January 2017 Cytochrome P450 enzymes (P450s) are some of the most
exquisite and versatile biocatalysts found in nature. In addition to their well-known roles in …