[HTML][HTML] Engineering cytochrome P450 enzyme systems for biomedical and biotechnological applications
Cytochrome P450 enzymes (P450s) are broadly distributed among living organisms and
play crucial roles in natural product biosynthesis, degradation of xenobiotics, steroid …
play crucial roles in natural product biosynthesis, degradation of xenobiotics, steroid …
The medicinal chemist's toolbox for late stage functionalization of drug-like molecules
T Cernak, KD Dykstra, S Tyagarajan… - Chemical Society …, 2016 - pubs.rsc.org
The advent of modern C–H functionalization chemistries has enabled medicinal chemists to
consider a synthetic strategy, late stage functionalization (LSF), which utilizes the C–H …
consider a synthetic strategy, late stage functionalization (LSF), which utilizes the C–H …
Biocatalytic oxidation reactions: a chemist's perspective
JJ Dong, E Fernández‐Fueyo… - Angewandte Chemie …, 2018 - Wiley Online Library
Oxidation chemistry using enzymes is approaching maturity and practical applicability in
organic synthesis. Oxidoreductases (enzymes catalysing redox reactions) enable chemists …
organic synthesis. Oxidoreductases (enzymes catalysing redox reactions) enable chemists …
[HTML][HTML] Recent advances in C–H functionalization
HML Davies, D Morton - The Journal of organic chemistry, 2016 - ACS Publications
C− H functionalization represents a paradigm shift from the standard logic of organic
synthesis. Instead of focusing on orchestration of selective reactions at functional groups, the …
synthesis. Instead of focusing on orchestration of selective reactions at functional groups, the …
Scalable biocatalytic C–H oxyfunctionalization reactions
S Chakrabarty, Y Wang, JC Perkins… - Chemical Society …, 2020 - pubs.rsc.org
Catalytic C–H oxyfunctionalization reactions have garnered significant attention in recent
years with their ability to streamline synthetic routes toward complex molecules …
years with their ability to streamline synthetic routes toward complex molecules …
Iron-and cobalt-catalyzed C (sp 3)–H bond functionalization reactions and their application in organic synthesis
Y Liu, T You, HX Wang, Z Tang, CY Zhou… - Chemical Society …, 2020 - pubs.rsc.org
Direct C–H bond functionalization catalyzed by non-precious transition metals is an
attractive strategy in synthetic chemistry. Compared with the precious metals rhodium …
attractive strategy in synthetic chemistry. Compared with the precious metals rhodium …
Cytochrome P450 monooxygenases in biotechnology and synthetic biology
VB Urlacher, M Girhard - Trends in biotechnology, 2019 - cell.com
Cytochromes P450 (P450 or CYP) are heme-containing enzymes that catalyze the
introduction of one atom of molecular oxygen into nonactivated C–H bonds, often in a regio …
introduction of one atom of molecular oxygen into nonactivated C–H bonds, often in a regio …
Optimizing oleaginous yeast cell factories for flavonoids and hydroxylated flavonoids biosynthesis
Plants possess myriads of secondary metabolites with a broad spectrum of health-promoting
benefits. To date, plant extraction is still the primary route to produce high-value natural …
benefits. To date, plant extraction is still the primary route to produce high-value natural …
Collective approach to advancing C–H functionalization
HML Davies, D Morton - ACS Central Science, 2017 - ACS Publications
C–H functionalization is a very active research field that has attracted the interest of
scientists from many disciplines. This Outlook describes the collaborative efforts within the …
scientists from many disciplines. This Outlook describes the collaborative efforts within the …
Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function
Covering: up to January 2017 Cytochrome P450 enzymes (P450s) are some of the most
exquisite and versatile biocatalysts found in nature. In addition to their well-known roles in …
exquisite and versatile biocatalysts found in nature. In addition to their well-known roles in …