The field of psychiatry is hampered by a lack of robust, reliable and valid biomarkers that can
aid in objectively diagnosing patients and providing individualized treatment …

The mesolimbic hypothesis has been a central dogma of schizophrenia for decades,
positing that aberrant functioning of midbrain dopamine projections to limbic regions causes …

The role of the prefrontal cortex (PFC) takes center stage among unanswered questions in
modern neuroscience. The PFC has a Janus-faced nature: it enables sophisticated cognitive …

The stagnation in drug development for schizophrenia highlights the need for better
translation between basic and clinical research. Understanding the neurobiology of …

The glutamate and dopamine hypotheses are leading theories of the pathoaetiology of
schizophrenia. Both were initially based on indirect evidence from pharmacological studies …

Context During the past 2 decades, a major transition in the clinical characterization of
psychotic disorders has occurred. The construct of a clinical high-risk (HR) state for …

Context A substantial proportion of people at clinical high risk of psychosis will develop a
psychotic disorder over time. However, the risk of transition to psychosis varies between …

Context Current drug treatments for schizophrenia are inadequate for many patients, and
despite 5 decades of drug discovery, all of the treatments rely on the same mechanism …

Context A substantial proportion of people at clinical high risk (HR) of psychosis will develop
a psychotic disorder over time. Cognitive deficits may predate the onset of psychosis and …

In light of the clinical evidence implicating dopamine in schizophrenia and the prominent
hypotheses put forth regarding alterations in dopaminergic transmission in this disease …