CCRL2 is a seven-transmembrane domain receptor that belongs to the chemokine receptor
family. At difference from other members of this family, CCRL2 does not promote chemotaxis …

Chemerin is a small chemotactic protein and a key player in initiating the early immune
response. As an adipokine, chemerin is also involved in energy homeostasis and the …

The inflammatory and IFN pathways of innate immunity play a key role in the resistance and
pathogenesis of coronavirus disease 2019 (COVID-19). Innate sensors and SARS-CoV-2 …

Macrophages are the key regulator of T-cell responses depending on their activation state.
CC motif chemokine receptor-like 2 (CCRL2), a nonsignaling atypical receptor originally …

Coronaviruses (CoVs) of genera α, β, γ, and δ encode proteins that have a PDZ-binding
motif (PBM) consisting of the last four residues of the envelope (E) protein (PBM core). PBMs …

Although the activation of innate immunity to treat a wide variety of cancers is gaining
increasing attention, it has been poorly investigated in human papillomavirus (HPV) …

Atypical chemokine receptors (ACKRs) are a group of seven-transmembrane spanning
serpentine receptors that are structurally homologous to classical G-protein-coupled …

Lung cancer (LC) is one of the leading causes of cancer-related deaths worldwide, with a
significant morbidity and mortality rate, endangering human life and health. The introduction …

The identification of new pathways supporting the myelodysplastic syndrome (MDS)
primitive cells growth is required to develop targeted therapies. Within myeloid …

Chemical induced carcinogenesis together with genetically engineered mouse models
represent important approaches for the study of the complex mechanisms involving …