The Major Histocompatibility Complex (MHC) locus encodes classical MHC class I and MHC
class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is …

T cells are a critical part of the adaptive immune system that are able to distinguish between
healthy and unhealthy cells. Upon recognition of protein fragments (peptides), activated T …

The ability to decode antigen specificities encapsulated in the sequences of rearranged T-
cell receptor (TCR) genes is critical for our understanding of the adaptive immune system …

Molecular simulations are a computational technique used to investigate the dynamics of
proteins and other molecules. The free energy landscape of these simulations is often …

T cell discrimination of self and non-self is predicated on αβ T cell receptor (TCR) co-
recognition of peptides presented by MHC molecules. Over the past 20 years, structurally …

T cell receptors (TCRs) are protein complexes formed by six different polypeptides. In most T
cells, TCRs are composed of αβ subunits displaying immunoglobulin-like variable domains …

Mucosal-associated invariant T cells (MAIT cells) express a semi-invariant T cell receptor
(TCR) α-chain, TRAV1-2–TRAJ33, and are activated by vitamin B metabolites bound by the …

The initiation of T cell antigen receptor signaling is a key step that can result in T cell
activation and the orchestration of an adaptive immune response. Early events in T cell …

Since the first crystal structure determinations of αβ T cell receptors (TCRs) bound to class I
MHC-peptide (pMHC) antigens in 1996, a sizable database of 24 class I and class II …

There is considerable controversy about the mechanism of T cell receptor (TCR) triggering,
the process by which the TCR tranduces signals across the plasma membrane after binding …