Most bacteria are surrounded by a peptidoglycan cell wall that defines their shape and
protects them from osmotic lysis. The expansion and division of this structure therefore plays …

The peptidoglycan (PG) cell wall is an extra-cytoplasmic glycopeptide polymeric structure
that protects bacteria from osmotic lysis and determines cellular shape. Since the cell wall …

The biological diversity of the unicellular bacteria—whether assessed by shape, food,
metabolism, or ecological niche—surely rivals (if not exceeds) that of the multicellular …

The bacterial enzymes FtsW and FtsI, encoded in the highly conserved dcw gene cluster,
are considered to be universally essential for the synthesis of septal peptidoglycan (PG) …

The peptidoglycan (PG) cell wall protects bacteria against osmotic lysis and determines cell
shape, making this structure a key antibiotic target. Peptidoglycan is a polymer of glycan …

Highlights•Class A PBPs are essential in most bacteria.•They provide a major contribution to
overall PG synthesis during growth and cell division.•Multiple protein? protein interactions …

Until recently, class A penicillin‐binding proteins (aPBPs) were the only enzymes known to
catalyze glycan chain polymerization from lipid II in bacteria. Hence, the discovery of two …

A cell wall made of the heteropolymer peptidoglycan (PG) surrounds most bacterial cells.
This essential surface layer is required to prevent lysis from internal osmotic pressure. The …

Cell division in Streptococcus pneumoniae (pneumococcus) is performed and regulated by
a protein complex consisting of at least 14 different protein elements; known as the …

Ovoid-shaped bacteria, such as Streptococcus pneumoniae (pneumococcus), have two
spatially separated peptidoglycan (PG) synthase nanomachines that locate zonally to the …