Addiction is associated with neuroplasticity in the corticostriatal brain circuitry that is
important for guiding adaptive behaviour. The hierarchy of corticostriatal information …

The prefrontal cortex plays an important role in shaping cognition and behavior. Many
studies have shown that medial prefrontal cortex (mPFC) plays a key role in seeking …

The past two decades have witnessed a dramatic accumulation of evidence indicating that
the excitatory amino acid glutamate plays an important role in drug addiction and …

Environmental conditions can dramatically influence the behavioral and neurochemical
effects of drugs of abuse. For example, stress increases the reinforcing effects of drugs and …

Learned associations between drugs and environment play an important role in addiction
and are thought to be encoded within specific patterns of sparsely distributed neurons called …

Development of pharmacotherapy to reduce relapse rates is one of the biggest challenges
in drug addiction research. The enduring nature of relapse suggests that it is maintained by …

In operant learning, initial reward-associated memories are thought to be distinct from
subsequent extinction-associated memories. Memories formed during operant learning are …

Conditioned drug craving and withdrawal elicited by cues paired with drug use or acute
withdrawal are among the many factors contributing to compulsive drug taking …

Relapse to cocaine-seeking behavior requires an increase in nucleus accumbens (NAc)
core glutamate transmission. Decreased expression of glutamate type I transporter (GLT1) …

We hypothesized that environmental enrichment in rats may reduce cocaine-seeking
behaviour elicited by cocaine-priming injections and by cocaine-associated cues. Rats …