[HTML][HTML] The potential roles of ATF family in the treatment of Alzheimer's disease

T Yang, Y Zhang, L Chen, ER Thomas, W Yu… - Biomedicine & …, 2023 - Elsevier
Activating transcription factors, ATFs, is a family of transcription factors that activate gene
expression and transcription by recognizing and combining the cAMP response element …

A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene

N Magusali, AC Graham, TM Piers, P Panichnantakul… - Brain, 2021 - academic.oup.com
Recently, we reported oligoadenylate synthetase 1 (OAS1) contributed to the risk of
Alzheimer's disease, by its enrichment in transcriptional networks expressed by microglia …

Melatonin: a promising neuroprotective agent for cerebral ischemia-reperfusion injury

M Tozihi, B Shademan, H Yousefi, CB Avci… - Frontiers in Aging …, 2023 - frontiersin.org
Cerebral ischemia-reperfusion (CIR) injury is initiated by the generation of reactive oxygen
species (ROS), which leads to the oxidation of cellular proteins, DNA, and lipids as an initial …

The GCN2/eIF2αK stress kinase regulates PP1 to ensure mitotic fidelity

V Stonyte, M Mastrangelopoulou, R Timmer… - EMBO …, 2023 - embopress.org
Abstract GCN2/eIF2αK4 is exclusively seen as an eIF2α kinase, which regulates
reprogramming of protein translation in response to stress. Here, we show that GCN2 has an …

Protein synthesis inhibition and loss of homeostatic functions in astrocytes from an Alzheimer's disease mouse model: a role for ER-mitochondria interaction

L Tapella, G Dematteis, M Moro, B Pistolato… - Cell death & …, 2022 - nature.com
Deregulation of protein synthesis and ER stress/unfolded protein response (ER stress/UPR)
have been reported in astrocytes. However, the relationships between protein synthesis …

The PKR/P38/RIPK1 signaling pathway as a therapeutic target in Alzheimer's disease

J Hugon, C Paquet - International Journal of Molecular Sciences, 2021 - mdpi.com
Neuropathological lesions in Alzheimer's disease (AD) include amyloid plaques formed by
the accumulation of amyloid peptides, neurofibrillary tangles made of hyperphosphorylated …

Roles and mechanisms of the protein quality control system in Alzheimer's disease

Y Liu, R Ding, Z Xu, Y Xue, D Zhang, Y Zhang… - International Journal of …, 2021 - mdpi.com
Alzheimer's disease (AD) is characterized by the deposition of senile plaques (SPs) and the
formation of neurofibrillary tangles (NTFs), as well as neuronal dysfunctions in the brain, but …

Alzheimer's disease in elderly COVID-19 patients: potential mechanisms and preventive measures

H Wang, J Lu, X Zhao, R Qin, K Song, Y Xu… - Neurological …, 2021 - Springer
Advanced age correlates with higher morbidity and mortality among patients affected with
the novel coronavirus disease 2019 (COVID-19). Because systemic inflammation and …

Steroidogenic Acute Regulatory Protein Mediated Variations of Gender-Specific Sex Neurosteroids in Alzheimer's Disease: Relevance to Hormonal Imbalance

PR Manna, S Yang, C Manna, H Waters… - Neuroscience & …, 2024 - Elsevier
The steroidogenic acute regulatory (StAR) protein mediates the rate-liming step in
neuro/steroid biosynthesis. Multifaceted changes during aging, disrupting the immune …

Proteostasis deregulation in neurodegeneration and its link with stress granules: focus on the scaffold and ribosomal protein RACK1

M Masi, A Attanzio, M Racchi, B Wolozin, S Borella… - Cells, 2022 - mdpi.com
The role of protein misfolding, deposition, and clearance has been the dominant topic in the
last decades of investigation in the field of neurodegeneration. The impairment of protein …