[HTML][HTML] The potential roles of ATF family in the treatment of Alzheimer's disease
T Yang, Y Zhang, L Chen, ER Thomas, W Yu… - Biomedicine & …, 2023 - Elsevier
Activating transcription factors, ATFs, is a family of transcription factors that activate gene
expression and transcription by recognizing and combining the cAMP response element …
expression and transcription by recognizing and combining the cAMP response element …
A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene
Recently, we reported oligoadenylate synthetase 1 (OAS1) contributed to the risk of
Alzheimer's disease, by its enrichment in transcriptional networks expressed by microglia …
Alzheimer's disease, by its enrichment in transcriptional networks expressed by microglia …
Melatonin: a promising neuroprotective agent for cerebral ischemia-reperfusion injury
Cerebral ischemia-reperfusion (CIR) injury is initiated by the generation of reactive oxygen
species (ROS), which leads to the oxidation of cellular proteins, DNA, and lipids as an initial …
species (ROS), which leads to the oxidation of cellular proteins, DNA, and lipids as an initial …
The GCN2/eIF2αK stress kinase regulates PP1 to ensure mitotic fidelity
V Stonyte, M Mastrangelopoulou, R Timmer… - EMBO …, 2023 - embopress.org
Abstract GCN2/eIF2αK4 is exclusively seen as an eIF2α kinase, which regulates
reprogramming of protein translation in response to stress. Here, we show that GCN2 has an …
reprogramming of protein translation in response to stress. Here, we show that GCN2 has an …
Protein synthesis inhibition and loss of homeostatic functions in astrocytes from an Alzheimer's disease mouse model: a role for ER-mitochondria interaction
Deregulation of protein synthesis and ER stress/unfolded protein response (ER stress/UPR)
have been reported in astrocytes. However, the relationships between protein synthesis …
have been reported in astrocytes. However, the relationships between protein synthesis …
The PKR/P38/RIPK1 signaling pathway as a therapeutic target in Alzheimer's disease
J Hugon, C Paquet - International Journal of Molecular Sciences, 2021 - mdpi.com
Neuropathological lesions in Alzheimer's disease (AD) include amyloid plaques formed by
the accumulation of amyloid peptides, neurofibrillary tangles made of hyperphosphorylated …
the accumulation of amyloid peptides, neurofibrillary tangles made of hyperphosphorylated …
Roles and mechanisms of the protein quality control system in Alzheimer's disease
Y Liu, R Ding, Z Xu, Y Xue, D Zhang, Y Zhang… - International Journal of …, 2021 - mdpi.com
Alzheimer's disease (AD) is characterized by the deposition of senile plaques (SPs) and the
formation of neurofibrillary tangles (NTFs), as well as neuronal dysfunctions in the brain, but …
formation of neurofibrillary tangles (NTFs), as well as neuronal dysfunctions in the brain, but …
Alzheimer's disease in elderly COVID-19 patients: potential mechanisms and preventive measures
H Wang, J Lu, X Zhao, R Qin, K Song, Y Xu… - Neurological …, 2021 - Springer
Advanced age correlates with higher morbidity and mortality among patients affected with
the novel coronavirus disease 2019 (COVID-19). Because systemic inflammation and …
the novel coronavirus disease 2019 (COVID-19). Because systemic inflammation and …
Steroidogenic Acute Regulatory Protein Mediated Variations of Gender-Specific Sex Neurosteroids in Alzheimer's Disease: Relevance to Hormonal Imbalance
PR Manna, S Yang, C Manna, H Waters… - Neuroscience & …, 2024 - Elsevier
The steroidogenic acute regulatory (StAR) protein mediates the rate-liming step in
neuro/steroid biosynthesis. Multifaceted changes during aging, disrupting the immune …
neuro/steroid biosynthesis. Multifaceted changes during aging, disrupting the immune …
Proteostasis deregulation in neurodegeneration and its link with stress granules: focus on the scaffold and ribosomal protein RACK1
The role of protein misfolding, deposition, and clearance has been the dominant topic in the
last decades of investigation in the field of neurodegeneration. The impairment of protein …
last decades of investigation in the field of neurodegeneration. The impairment of protein …