Mechanisms of action of fluvoxamine for COVID-19: a historical review

Y Hashimoto, T Suzuki, K Hashimoto - Molecular psychiatry, 2022 - nature.com
The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by the novel severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) accelerates the discovery of …

Repurposing of CNS drugs to treat COVID-19 infection: targeting the sigma-1 receptor

K Hashimoto - European archives of psychiatry and clinical …, 2021 - Springer
The novel coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). The escalating number of SARS-CoV-2-infected …

N, N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo

JA Morales-Garcia, J Calleja-Conde… - Translational …, 2020 - nature.com
Abstract N, N-dimethyltryptamine (DMT) is a component of the ayahuasca brew traditionally
used for ritual and therapeutic purposes across several South American countries. Here, we …

Sigma receptors [σ Rs]: biology in normal and diseased states

CG Rousseaux, SF Greene - Journal of Receptors and Signal …, 2016 - Taylor & Francis
This review compares the biological and physiological function of Sigma receptors [σRs] and
their potential therapeutic roles. Sigma receptors are widespread in the central nervous …

[PDF][PDF] Treatment of 95 post-Covid patients with SSRIs

CP Rus, BEK de Vries, IEJ de Vries, I Nutma… - Scientific reports, 2023 - nature.com
Abstract After Covid-19 infection, 12.5% develops post-Covid-syndrome (PCS). Symptoms
indicate numerous affected organ systems. After a year, chronic fatigue, dysautonomia and …

Sigmar1's molecular, cellular, and biological functions in regulating cellular pathophysiology

R Aishwarya, CS Abdullah, M Morshed… - Frontiers in …, 2021 - frontiersin.org
The Sigma 1 receptor (Sigmar1) is a ubiquitously expressed multifunctional inter-organelle
signaling chaperone protein playing a diverse role in cellular survival. Recessive mutation in …

Sigma-1 receptor chaperone and brain-derived neurotrophic factor: emerging links between cardiovascular disease and depression

K Hashimoto - Progress in neurobiology, 2013 - Elsevier
Epidemiological studies have demonstrated a close relationship between depression and
cardiovascular disease (CVD). Although it is known that the central nervous system (CNS) …

Psychedelic treatment for trauma-related psychological and cognitive impairment among US special operations forces veterans

AK Davis, LA Averill, ND Sepeda… - Chronic …, 2020 - journals.sagepub.com
Background US Special Operations Forces Veterans are at increased risk for a variety of
mental health problems and cognitive impairment associated with military service. Current …

The role of sigma-1 receptor, an intracellular chaperone in neurodegenerative diseases

B Penke, L Fulop, M Szucs… - Current …, 2018 - ingentaconnect.com
Background: Widespread protein aggregation occurs in the living system under stress or
during aging, owing to disturbance of endoplasmic reticulum (ER) proteostasis. Many …

Oestrogens and progestagens: synthesis and action in the brain

MF Rossetti, MJ Cambiasso… - Journal of …, 2016 - Wiley Online Library
When steroids, such as pregnenolone, progesterone and oestrogen, are synthesised de
novo in neural tissues, they are more specifically referred to as neurosteroids. These …