Intelligent poly (l-histidine)-based nanovehicles for controlled drug delivery

Y Zhang, I Kim, Y Lu, Y Xu, DG Yu, W Song - Journal of Controlled Release, 2022 - Elsevier
Stimuli-responsive drug delivery systems based on polymeric nanovehicles are among the
most promising treatment regimens for malignant cancers. Such intelligent systems that …

Host defense peptide mimicking antimicrobial amino acid polymers and beyond: Design, synthesis and biomedical applications

Y Wu, K Chen, J Wang, M Chen, Y Chen, Y She… - Progress in Polymer …, 2023 - Elsevier
Microbial infections endanger human health and life. Conventional antibiotics has saved
countless human lives, however, is seriously challenged by the quick emergence of …

Beyond nylon 6: Polyamides via ring opening polymerization of designer lactam monomers for biomedical applications

M Varghese, MW Grinstaff - Chemical Society Reviews, 2022 - pubs.rsc.org
Ring opening polymerization (ROP) of lactams is a highly efficient and versatile method to
synthesize polyamides. Within the last ten years, significant advances in polymerization …

[HTML][HTML] Membrane-disruptive peptides/peptidomimetics-based therapeutics: Promising systems to combat bacteria and cancer in the drug-resistant era

L Lin, J Chi, Y Yan, R Luo, X Feng, Y Zheng… - … Pharmaceutica Sinica B, 2021 - Elsevier
Membrane-disruptive peptides/peptidomimetics (MDPs) are antimicrobials or
anticarcinogens that present a general killing mechanism through the physical disruption of …

Peptide Polymer‐Doped Cement Acting as an Effective Treatment of MRSA‐Infected Chronic Osteomyelitis

Y Wu, Y Lin, Z Cong, K Chen, X Xiao… - Advanced Functional …, 2022 - Wiley Online Library
Chronic osteomyelitis is a painful and serious disease normally caused by infected surgical
prostheses or infected fractures. Currently, antibiotic‐loaded cements are extensively used …

Polypeptides–drug conjugates for anticancer therapy

Y Zhang, P He, P Zhang, X Yi, C Xiao… - Advanced healthcare …, 2021 - Wiley Online Library
Polypeptides are an important class of biodegradable polymers that have been widely used
in drug delivery field. Owing to the controllable synthesis and robust side chain …

Microbial Metabolite Inspired β‐Peptide Polymers Displaying Potent and Selective Antifungal Activity

D Zhang, C Shi, Z Cong, Q Chen, Y Bi… - Advanced …, 2022 - Wiley Online Library
Potent and selective antifungal agents are urgently needed due to the quick increase of
serious invasive fungal infections and the limited antifungal drugs available. Microbial …

An effective strategy to develop potent and selective antifungal agents from cell penetrating peptides in tackling drug-resistant invasive fungal infections

Y Wu, W Jiang, Z Cong, K Chen, Y She… - Journal of Medicinal …, 2022 - ACS Publications
The high mortality rate of invasive fungal infections and quick emergence of drug-resistant
fungal pathogens urgently call for potent antifungal agents. Inspired by the cell penetrating …

A natural polyphenol-functionalized chitosan/gelatin sponge for accelerating hemostasis and infected wound healing

Y Sun, T Miao, Y Wang, X Wang, J Lin, N Zhao… - Biomaterials …, 2023 - pubs.rsc.org
Natural polymers have been particularly appealing for constructing hemostatic
materials/devices, but it is still desirable to develop new natural polymer-based biomaterials …

Switching from membrane disrupting to membrane crossing, an effective strategy in designing antibacterial polypeptide

H Zhang, Q Chen, J Xie, Z Cong, C Cao, W Zhang… - Science …, 2023 - science.org
Drug-resistant bacterial infections have caused serious threats to human health and call for
effective antibacterial agents that have low propensity to induce antimicrobial resistance …