Physiology and pathophysiology of human airway mucus
The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …
Mucus, mucins, and cystic fibrosis
Cystic fibrosis (CF) is both the most common and most lethal genetic disease in the
Caucasian population. CF is caused by mutations in the cystic fibrosis transmembrane …
Caucasian population. CF is caused by mutations in the cystic fibrosis transmembrane …
Longitudinal effects of elexacaftor/tezacaftor/ivacaftor on sputum viscoelastic properties, airway infection and inflammation in patients with cystic fibrosis
L Schaupp, A Addante, M Völler… - European …, 2023 - Eur Respiratory Soc
Background Recent studies demonstrated that the triple combination cystic fibrosis
transmembrane conductance regulator (CFTR) modulator therapy elexacaftor/tezacaftor …
transmembrane conductance regulator (CFTR) modulator therapy elexacaftor/tezacaftor …
[HTML][HTML] IL-1β dominates the promucin secretory cytokine profile in cystic fibrosis
Cystic fibrosis (CF) lung disease is characterized by early and persistent mucus
accumulation and neutrophilic inflammation in the distal airways. Identification of the factors …
accumulation and neutrophilic inflammation in the distal airways. Identification of the factors …
TMEM16A potentiation: a novel therapeutic approach for the treatment of cystic fibrosis
HL Danahay, S Lilley, R Fox, H Charlton… - American journal of …, 2020 - atsjournals.org
Rationale: Enhancing non–CFTR (cystic fibrosis transmembrane conductance regulator)-
mediated anion secretion is an attractive therapeutic approach for the treatment of cystic …
mediated anion secretion is an attractive therapeutic approach for the treatment of cystic …
Progression of cystic fibrosis lung disease from childhood to adulthood: neutrophils, neutrophil extracellular trap (NET) formation, and NET degradation
MA Khan, ZS Ali, N Sweezey, H Grasemann… - Genes, 2019 - mdpi.com
Genetic defects in cystic fibrosis (CF) transmembrane conductance regulator (CFTR) gene
cause CF. Infants with CFTR mutations show a peribronchial neutrophil infiltration prior to …
cause CF. Infants with CFTR mutations show a peribronchial neutrophil infiltration prior to …
Polymeric nitric oxide delivery nanoplatforms for treating cancer, cardiovascular diseases, and infection
The shortened Abstract is as follows: Therapeutic gas nitric oxide (NO) has demonstrated
the unique advances in biomedical applications due to its prominent role in regulating …
the unique advances in biomedical applications due to its prominent role in regulating …
Airway mucus hyperconcentration in non–cystic fibrosis bronchiectasis
KA Ramsey, ACH Chen, G Radicioni… - American journal of …, 2020 - atsjournals.org
Rationale: Non–cystic fibrosis bronchiectasis is characterized by airway mucus
accumulation and sputum production, but the role of mucus concentration in the …
accumulation and sputum production, but the role of mucus concentration in the …
Treatment of cystic fibrosis airway cells with CFTR modulators reverses aberrant mucus properties via hydration
Question Cystic fibrosis (CF) is characterised by the accumulation of viscous adherent
mucus in the lungs. While several hypotheses invoke a direct relationship with cystic fibrosis …
mucus in the lungs. While several hypotheses invoke a direct relationship with cystic fibrosis …
The MUC5B mucin polymer is dominated by repeating structural motifs and its topology is regulated by calcium and pH
The polymeric mucin MUC5B provides the structural and functional framework of respiratory
mucus, conferring both viscoelastic and antimicrobial properties onto this vital protective …
mucus, conferring both viscoelastic and antimicrobial properties onto this vital protective …