Treatment strategies for cryptococcal infection: challenges, advances and future outlook
Cryptococcus spp., in particular Cryptococcus neoformans and Cryptococcus gattii, have an
enormous impact on human health worldwide. The global burden of cryptococcal meningitis …
enormous impact on human health worldwide. The global burden of cryptococcal meningitis …
Antifungal therapy: new advances in the understanding and treatment of mycosis
L Scorzoni, ACA de Paula e Silva, CM Marcos… - Frontiers in …, 2017 - frontiersin.org
The high rates of morbidity and mortality caused by fungal infections are associated with the
current limited antifungal arsenal and the high toxicity of the compounds. Additionally …
current limited antifungal arsenal and the high toxicity of the compounds. Additionally …
Induction of memory-like dendritic cell responses in vivo
Dendritic cells (DCs), a vital component of the innate immune system, are considered to lack
antigen specificity and be devoid of immunological memory. Strategies that can induce …
antigen specificity and be devoid of immunological memory. Strategies that can induce …
[HTML][HTML] Fungal vaccines, mechanism of actions and immunology: A comprehensive review
S Nami, R Mohammadi, M Vakili, K Khezripour… - Biomedicine & …, 2019 - Elsevier
Fungal infections include a wide range of opportunistic and invasive diseases. Two of four
major fatal diseases in patients with human immunodeficiency virus (HIV) infection are …
major fatal diseases in patients with human immunodeficiency virus (HIV) infection are …
Immunotherapeutic approaches to treatment of fungal diseases
Fungal infections cause morbidity worldwide and are associated with an unacceptably high
mortality despite the availability of antifungal drugs. The incidence of mycoses is rising …
mortality despite the availability of antifungal drugs. The incidence of mycoses is rising …
The Intracellular Life of Cryptococcus neoformans
Cryptococcus neoformans is a fungal pathogen with worldwide distribution. Serological
studies of human populations show a high prevalence of human infection, which rarely …
studies of human populations show a high prevalence of human infection, which rarely …
Harnessing the immune response to fungal pathogens for vaccine development
A Rivera, J Lodge, C Xue - Annual review of microbiology, 2022 - annualreviews.org
Invasive fungal infections are emerging diseases that kill over 1.5 million people per year
worldwide. With the increase of immunocompromised populations, the incidence of invasive …
worldwide. With the increase of immunocompromised populations, the incidence of invasive …
CD4+ T Cells Orchestrate Lethal Immune Pathology despite Fungal Clearance during Cryptococcus neoformans Meningoencephalitis
Cryptococcus neoformans is a major fungal pathogen that disseminates to the central
nervous system (CNS) to cause fatal meningoencephalitis, but little is known about immune …
nervous system (CNS) to cause fatal meningoencephalitis, but little is known about immune …
Cryptococcus and Phagocytes: Complex Interactions that Influence Disease Outcome
Cryptococcus neoformans and C. gattii are fungal pathogens that cause life-threatening
disease. These fungi commonly enter their host via inhalation into the lungs where they …
disease. These fungi commonly enter their host via inhalation into the lungs where they …
Induction of protective immunity to cryptococcal infection in mice by a heat-killed, chitosan-deficient strain of Cryptococcus neoformans
R Upadhya, WC Lam, B Maybruck, CA Specht… - MBio, 2016 - Am Soc Microbiol
Cryptococcus neoformans is a major opportunistic fungal pathogen that causes fatal
meningoencephalitis in immunocompromised individuals and is responsible for a large …
meningoencephalitis in immunocompromised individuals and is responsible for a large …