There is currently an unmet need for better biomarkers across the spectrum of renal
diseases. In this paper, we revisit the role of beta-2 microglobulin (β2M) as a biomarker in …

Background Several studies have suggested that patients with kidney failure may benefit
from high-dose hemodiafiltration as compared with standard hemodialysis. However, given …

Hemodialysis has saved many lives, albeit with significant residual mortality. Although poor
outcomes may reflect advanced age and comorbid conditions, hemodialysis per se may …

Large cohort studies suggest that high convective volumes associated with online
hemodiafiltration may reduce the risk of mortality/morbidity compared to optimal high-flux …

Hemodynamic stress during hemodialysis (HD) results in recurrent segmental ischemic
injury (myocardial stunning) that drives cumulative cardiac damage. We performed a fully …

Aggressive removal of middle molecules or larger low-molecular-weight proteins (LMWPs)
has been a growing concern following studies on their harmful effects on the mortality and …

Background: A novel class of membranes, medium cut-off (MCO) membranes, has recently
been designed to achieve interesting removal capacities for middle and large middle …

Background With its convective component, hemodiafiltration (HDF) provides better middle
molecule clearance compared with hemodialysis (HD) and is postulated to improve survival …

Haemodialysis is a life-saving renal replacement modality for end-stage renal disease, but
this therapy also represents a major challenge to the intravascular innate immune system …

Cardiovascular disease (CVD) remains a major cause of high morbidity and mortality in
patients with chronic kidney disease (CKD). Numerous CVD risk factors in CKD patients …