Nearly half a century has passed since the discovery of cytoplasmic inheritance of human
chloramphenicol resistance. The inheritance was then revealed to take place maternally by …

Since the discovery of dopamine as a neurotransmitter in the 1950s, P arkinson's disease
(PD) research has generated a rich and complex body of knowledge, revealing PD to be an …

A shared neuropathological feature of idiopathic Parkinson's disease, dementia with Lewy
bodies, and multiple system atrophy is the development of intracellular aggregates of α …

Parkinson's disease (PD) is a neurodegenerative disorder affecting mainly the dopaminergic
neurons of the nigrostriatal pathway, a neuronal circuit involved in the control of movements …

In addition to the classic motor symptoms, Parkinson's disease (PD) is associated with a
variety of nonmotor symptoms that significantly reduce quality of life, even in the early stages …

Nowadays it is well accepted that in Parkinson's disease (PD), the neurodegenerative
process occurs in stages and that damage to other areas precedes the neuronal loss in the …

Patients with Parkinson's disease (PD) exhibit multifaceted changes in neurophysiological
brain activity, hypothesized to represent a global cortical slowing effect. Using task-free …

Background The variability in the clinical phenotype of Parkinson's disease seems to
suggest the existence of several subtypes of the disease. To test this hypothesis we …

Background: A number of epidemiologic studies of Parkinson's disease (PD) have been
conducted worldwide over the years. Although every study reported the rise in prevalence …

A diagnosis of Parkinson's disease is classically established after the manifestation of motor
symptoms such as rigidity, bradykinesia, and tremor. However, a growing body of evidence …