A review of reproductive toxicity of microcystins

L Chen, J Chen, X Zhang, P Xie - Journal of hazardous materials, 2016 - Elsevier
Animal studies provide strong evidence of positive associations between microcystins (MCs)
exposure and reproductive toxicity, representing a threat to human reproductive health and …

Toxic mechanisms of microcystins in mammals

NL McLellan, RA Manderville - Toxicology research, 2017 - academic.oup.com
Microcystins, such as microcystin-leucine arginine (MC-LR), are some of the most toxic and
prevalent cyanotoxins produced by cyanobacteria in freshwater and saltwater algal blooms …

Update on the adverse effects of microcystins on the liver

L Shi, X Du, H Liu, X Chen, Y Ma, R Wang, Z Tian… - Environmental …, 2021 - Elsevier
Microcystins (MCs) are the most common cyanobacteria toxins in eutrophic water, which
have strong hepatotoxicity. In the past decade, epidemiological and toxicological studies on …

Mechanisms of microcystin-induced cytotoxicity and apoptosis

L Chen, P Xie - Mini reviews in medicinal chemistry, 2016 - ingentaconnect.com
In recent years, cyanobacterial blooms have dramatically increased and become an
ecological disaster worldwide. Cyanobacteria are also known to produce a wide variety of …

Mechanisms of microcystin-LR-induced cytoskeletal disruption in animal cells

M Zhou, W Tu, J Xu - Toxicon, 2015 - Elsevier
Abstract Microcystin-LR (MC-LR), a potent hepatotoxin produced by certain bloom-forming
cyanobacteria, covalently binds to serine/threonine protein phosphatases and acts as an …

The role of PP2A-associated proteins and signal pathways in microcystin-LR toxicity

J Liu, Y Sun - Toxicology letters, 2015 - Elsevier
Microcystins are a family of monocyclic heptapeptides produced by cyanobacteria during
water blooms. Microcystin-LR (MC-LR) is the most common member of this family …

Pro-and anti-inflammatory cytokine expression in carp blood and head kidney leukocytes exposed to cyanotoxin stress–an in vitro study

A Rymuszka, Ł Adaszek - Fish & Shellfish Immunology, 2012 - Elsevier
Cyanotoxins are toxic, secondary metabolites produced by different species of
cyanobacteria that are present all over the world in aquatic environments. No data are …

Review of cyanotoxicity studies based on cell cultures

I Sazdova, M Keremidarska-Markova… - Journal of …, 2022 - Wiley Online Library
Cyanotoxins (CTs) are a large and diverse group of toxins produced by the peculiar
photosynthetic prokaryotes of the domain Cyanoprokaryota. Toxin‐producing aquatic …

Hepatic NLRP3-Derived Hsp70 Binding to TLR4 Mediates MASLD to MASH Progression upon Inhibition of PP2A by Harmful Algal Bloom Toxin Microcystin, a Second …

S Roy, P Saha, D Bose, A Trivedi, M More… - International journal of …, 2023 - mdpi.com
Harmful algal bloom toxin microcystin has been associated with metabolic dysfunction-
associated steatotic liver disease (MASLD) progression and hepatocellular carcinoma …

Cell stress promotes the association of phosphorylated HspB1 with F-actin

JP Clarke, KM Mearow - PloS one, 2013 - journals.plos.org
Previous studies have suggested that the small heat shock protein, HspB1, has a direct
influence on the dynamics of cytoskeletal elements, in particular, filamentous actin (F-actin) …