MicroRNAs are involved in the crucial processes of development and diseases and have
emerged as a new class of biomarkers. The field of DNA nanotechnology has shown great …

Glioblastoma (GBM) is the most prevalent and deadly primary brain tumor type, with a
discouragingly low survival rate and few effective treatments. An important function of the …

Epitranscriptomic RNA modifications can regulate fundamental biological processes, but we
lack approaches to map modification sites and probe writer enzymes. Here we present a …

The detection of nucleic acid marker is essential for accurate and timely diagnosis and
prognosis of different types of diseases. However, the sensitivity and specificity of the assay …

Summary N 6-methyladenosine (m 6 A) modifications play crucial roles in RNA metabolism.
How m 6 A regulates RNA polymerase II (RNA Pol II) transcription remains unclear. We find …

MicroRNAs (miRNA) load onto AGO proteins to target mRNAs for translational repression or
degradation. However, miRNA degradation can be triggered when extensively base-paired …

Up to 80% of the human genome produces “dark matter” RNAs, most of which are
noncapped RNAs (napRNAs) that frequently act as noncoding RNAs (ncRNAs) to modulate …

RNA interference (RNAi) is a powerful tool for sequence-specific gene knockdown in
therapeutic and research applications. However, spatiotemporal control of RNAi is required …

The ability to form a dormant spore is essential for the survival of the anaerobic pathogen,
Clostridioides difficile, outside of the mammalian gastrointestinal tract. The initiation of …

MicroRNA (miRNA) homeostasis is crucial for the posttranscriptional regulation of their
target genes during development and in disease states. miRNAs are derived from primary …