Strategies to access biosynthetic novelty in bacterial genomes for drug discovery

F Hemmerling, J Piel - Nature Reviews Drug Discovery, 2022 - nature.com
Bacteria provide a rich source of natural products with potential therapeutic applications,
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …

Defensive symbioses of animals with prokaryotic and eukaryotic microorganisms

LV Flórez, PHW Biedermann, T Engl… - Natural Product …, 2015 - pubs.rsc.org
Covering: through 2014 Many organisms team up with microbes for defense against
predators, parasites, parasitoids, or pathogens. Here we review the described protective …

[HTML][HTML] Immune properties of invertebrate phenoloxidases

L Cerenius, K Söderhäll - Developmental & Comparative Immunology, 2021 - Elsevier
Melanin production from different types of phenoloxidases (POs) confers immunity from a
variety of pathogens ranging from viruses and microorganisms to parasites. The arthropod …

Diversity and natural functions of antibiotics produced by beneficial and plant pathogenic bacteria

JM Raaijmakers, M Mazzola - Annual review of phytopathology, 2012 - annualreviews.org
Soil-and plant-associated environments harbor numerous bacteria that produce antibiotic
metabolites with specific or broad-spectrum activities against coexisting microorganisms …

The proPO-system: pros and cons for its role in invertebrate immunity

L Cerenius, BL Lee, K Söderhäll - Trends in immunology, 2008 - cell.com
Melanisation is an important immune response in many invertebrates. Recent evidence also
strongly implies that the melanisation (prophenoloxidase activating) cascade is intimately …

Insect prophenoloxidase: the view beyond immunity

A Lu, Q Zhang, J Zhang, B Yang, K Wu, W Xie… - Frontiers in …, 2014 - frontiersin.org
Insect prophenoloxidase (PPO) is an important innate immunity protein due to its
involvement in cellular and humoral defense. It belongs to a group of type-3 copper …

Metabolites from symbiotic bacteria

J Piel - Natural product reports, 2009 - pubs.rsc.org
Metabolites from symbiotic bacteria - Natural Product Reports (RSC Publishing) DOI:10.1039/B703499G
Royal Society of Chemistry View PDF VersionPrevious ArticleNext Article DOI: 10.1039/B703499G …

Proteolytic cascades and their involvement in invertebrate immunity

L Cerenius, S Kawabata, BL Lee, M Nonaka… - Trends in biochemical …, 2010 - cell.com
Bacteria and other potential pathogens are cleared rapidly from the body fluids of
invertebrates by the immediate response of the innate immune system. Proteolytic cascades …

Regulation of stilbene biosynthesis in plants

AS Dubrovina, KV Kiselev - Planta, 2017 - Springer
Main conclusion This review analyzes the advances in understanding the natural signaling
pathways and environmental factors regulating stilbene biosynthesis. We also discuss the …

Entomopathogenic bacteria as a source of secondary metabolites

HB Bode - Current opinion in chemical biology, 2009 - Elsevier
Insects are not only the most diverse group of animals on our planet, but also a huge
reservoir for unusual microorganism which are a rich source of pharmaceutically interesting …