Pyruvate is a keystone molecule critical for numerous aspects of eukaryotic and human
metabolism. Pyruvate is the end-product of glycolysis, is derived from additional sources in …

Despite worldwide economic and scientific development, more than a quarter of the world's
population remains anemic, and about half of this burden is a result of iron deficiency …

An international, multicenter registry was established to collect retrospective and prospective
clinical data on patients with pyruvate kinase (PK) deficiency, the most common glycolytic …

Background Pyruvate kinase deficiency is caused by mutations in PKLR and leads to
congenital hemolytic anemia. Mitapivat is an oral, small-molecule allosteric activator of …

Over the last several decades, our understanding of the genetic variation, pathophysiology,
and complications of the hemolytic anemia associated with red cell pyruvate kinase …

Pyruvate kinase deficiency (PKD) is an autosomal-recessive enzyme defect of the glycolytic
pathway that causes congenital nonspherocytic hemolytic anemia. The diagnosis and …

Novel therapies in development have brought a new focus on pyruvate kinase deficiency
(PKD), the most common congenital haemolytic anaemia due to a glycolytic enzyme …

Pyruvate kinase (PK) deficiency is a rare recessive congenital hemolytic anemia caused by
mutations in the PKLR gene. This study reports the molecular features of 257 patients …

Red cell pyruvate kinase (PK) deficiency is the most common glycolytic defect associated
with congenital non-spherocytic hemolytic anemia. The disease, transmitted as an …

Pyruvate kinase deficiency (PKD) is a rare autosomal recessive disease marked by chronic
hemolytic anemia of various severity and frequent complications including gallstones …