Knowledge discovery in medicine: Current issue and future trend

N Esfandiari, MR Babavalian, AME Moghadam… - Expert Systems with …, 2014 - Elsevier
Data mining is a powerful method to extract knowledge from data. Raw data faces various
challenges that make traditional method improper for knowledge extraction. Data mining is …

[HTML][HTML] Data mining in healthcare: Applying strategic intelligence techniques to depict 25 years of research development

ML Kolling, LB Furstenau, MK Sott, B Rabaioli… - International journal of …, 2021 - mdpi.com
In order to identify the strategic topics and the thematic evolution structure of data mining
applied to healthcare, in this paper, a bibliometric performance and network analysis …

Model‐guided microarray implicates the retromer complex in Alzheimer's disease

SA Small, K Kent, A Pierce, C Leung… - Annals of Neurology …, 2005 - Wiley Online Library
Although, in principle, gene expression profiling is well suited to isolate pathogenic
molecules associated with Alzheimer's disease (AD), techniques such as microarray present …

ABCG2 is upregulated in Alzheimer's brain with cerebral amyloid angiopathy and may act as a gatekeeper at the blood–brain barrier for Aβ1–40 peptides

H Xiong, D Callaghan, A Jones, J Bai… - Journal of …, 2009 - Soc Neuroscience
Alzheimer's disease (AD) is characterized by accumulation and deposition of Aβ peptides in
the brain. Aβ deposition in cerebrovessels occurs in many AD patients and results in …

Knowledge and intelligent computing system in medicine

B Pandey, RB Mishra - Computers in biology and medicine, 2009 - Elsevier
Knowledge-based systems (KBS) and intelligent computing systems have been used in the
medical planning, diagnosis and treatment. The KBS consists of rule-based reasoning …

[HTML][HTML] Sex of the cell dictates its response: differential gene expression and sensitivity to cell death inducing stress in male and female cells

C Penaloza, B Estevez, S Orlanski, M Sikorska… - The FASEB …, 2009 - ncbi.nlm.nih.gov
Sexual dimorphisms are typically attributed to the hormonal differences arising once sex
differentiation has occurred. However, in some sexually dimorphic diseases that differ in …

Pharmacogenomics in Alzheimer's disease

R Cacabelos - … in Drug Discovery and Development: From Bench to …, 2008 - Springer
Pharmacological treatment in Alzheimer's disease (AD) accounts for 10–20% of direct costs,
and fewer than 20% of AD patients are moderate responders to conventional drugs …

[HTML][HTML] A computational analysis of protein-protein interaction networks in neurodegenerative diseases

J Goñi, FJ Esteban, NV de Mendizábal, J Sepulcre… - BMC systems …, 2008 - Springer
Background Recent developments have meant that network theory is making an important
contribution to the topological study of biological networks, such as protein-protein …

Dissecting complex and multifactorial nature of Alzheimer's disease pathogenesis: a clinical, genomic, and systems biology perspective

P Talwar, J Sinha, S Grover, C Rawat… - Molecular …, 2016 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by loss
of memory and other cognitive functions. AD can be classified into familial AD (FAD) and …

[HTML][HTML] Common transcriptional signatures in brain tissue from patients with HIV-associated neurocognitive disorders, Alzheimer's disease, and Multiple Sclerosis

A Borjabad, DJ Volsky - Journal of Neuroimmune Pharmacology, 2012 - Springer
Abstract HIV-Associated Neurocognitive Disorders (HAND) is a common manifestation of
HIV infection that afflicts about 50% of HIV-positive individuals. As people with access to …