Mitochondria as a therapeutic target for common pathologies
MP Murphy, RC Hartley - Nature Reviews Drug Discovery, 2018 - nature.com
Although the development of mitochondrial therapies has largely focused on diseases
caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial …
caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial …
Mitochondria-targeted triphenylphosphonium-based compounds: syntheses, mechanisms of action, and therapeutic and diagnostic applications
Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …
[HTML][HTML] Ischemia/reperfusion
T Kalogeris, CP Baines, M Krenz… - Comprehensive …, 2016 - ncbi.nlm.nih.gov
Ischemic disorders, such as myocardial infarction, stroke, and peripheral vascular disease,
are the most common causes of debilitating disease and death in westernized cultures. The …
are the most common causes of debilitating disease and death in westernized cultures. The …
[HTML][HTML] Antioxidant responses and cellular adjustments to oxidative stress
C Espinosa-Diez, V Miguel, D Mennerich, T Kietzmann… - Redox biology, 2015 - Elsevier
Redox biological reactions are now accepted to bear the Janus faceted feature of promoting
both physiological signaling responses and pathophysiological cues. Endogenous …
both physiological signaling responses and pathophysiological cues. Endogenous …
A unifying mechanism for mitochondrial superoxide production during ischemia-reperfusion injury
Ischemia-reperfusion (IR) injury occurs when blood supply to an organ is disrupted—
ischemia—and then restored—reperfusion—leading to a burst of reactive oxygen species …
ischemia—and then restored—reperfusion—leading to a burst of reactive oxygen species …
Metabolic control of cell death
Background For several decades, intermediate metabolism and signal transduction have
been considered two independent entities. On one side stood the catabolic and anabolic …
been considered two independent entities. On one side stood the catabolic and anabolic …
Mitochondria as a therapeutic target for ischemic stroke
Z He, N Ning, Q Zhou, SE Khoshnam… - Free Radical Biology and …, 2020 - Elsevier
Stroke is the leading cause of death and physical disability worldwide. Mitochondrial
dysfunction has been considered as one of the hallmarks of ischemic stroke and contributes …
dysfunction has been considered as one of the hallmarks of ischemic stroke and contributes …
Mitochondrial function, biology, and role in disease: a scientific statement from the American Heart Association
E Murphy, H Ardehali, RS Balaban, F DiLisa… - Circulation …, 2016 - Am Heart Assoc
Cardiovascular disease is a major leading cause of morbidity and mortality in the United
States and elsewhere. Alterations in mitochondrial function are increasingly being …
States and elsewhere. Alterations in mitochondrial function are increasingly being …
Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I
ET Chouchani, C Methner, SM Nadtochiy, A Logan… - Nature medicine, 2013 - nature.com
Oxidative damage from elevated production of reactive oxygen species (ROS) contributes to
ischemia-reperfusion injury in myocardial infarction and stroke. The mechanism by which …
ischemia-reperfusion injury in myocardial infarction and stroke. The mechanism by which …
Multifunctional nanoplatforms for subcellular delivery of drugs in cancer therapy
To achieve highly effective treatment to diseases, successful delivery of drugs with a carrier
into the specific organelles (nucleus, mitochondria, lysosomes, etc.) is of great importance …
into the specific organelles (nucleus, mitochondria, lysosomes, etc.) is of great importance …