Several synthetic heterocyclic small molecules like imiquimod, resiquimod, CL097, CL075,
bromopirone, tilorone, loxoribine and isatoribine demonstrated TLR7/8 agonistic activity and …

Hepatitis B virus (HBV) infection is a public health threat worldwide and characterized by a
dysfunctional immune response. In the present work, a new series of benzimidazole …

A novel series of 2, 4-diaminoquinazolines was identified as potent dual Toll-like receptor
(TLR) 7 and 8 agonists with reduced off-target activity. The stereochemistry of the amino …

The Suzuki–Miyaura cross coupling reaction uses a metal catalyst to create carbon–carbon
bonds from organoboron reagents and organo (pseudo) halides. By careful adjustment of …

B cells played an important role in Schistosoma infection-induced diseases. TLR7 is an
intracellular member of the innate immune receptor. The role of TLR7 on B cells mediated …

Adjuvants are substances added to vaccines to enhance antigen-specific immune
responses or to protect antigens from rapid elimination. As pattern recognition receptors, Toll …

Hepatitis B virus (HBV) infection is a worldwide threat to public health. In this work, a series
of novel quinazolinone derivatives (5a-q) were synthesized and evaluated as novel anti …

Toll‐like receptors (TLRs) play an important role in regulating immune responses during
pathogen infection. However, roles of TLRs on T cells reside in the mesenteric lymph node …

Due to the potencies in the treatments of cancer, infectious diseases, and autoimmune
diseases, the developments of human TLR8 (hTLR8) agonists and antagonists have …

Toll-like receptors (TLRs) are important pattern recognition receptors to human innate
immunity, which can recognize pathogen-associated molecular patterns and initiate innate …