Since their discovery 20 years ago, miRNAs have attracted much attention from all areas of
biology. These short (∼ 22 nt) non-coding RNA molecules are highly conserved in evolution …

Activity-dependent changes in the strength of synaptic connections are fundamental to the
formation and maintenance of memory. The mechanisms underlying persistent changes in …

Tristetraprolin (TTP) is an RNA-binding protein that controls the inflammatory response by
limiting the expression of several proinflammatory cytokines. TTP post-transcriptionally …

MicroRNAs (miRNAs) inhibit mRNA expression in general by base pairing to the 3′ UTR of
target mRNAs and consequently inhibiting translation and/or initiating poly (A) tail …

Yap is the key component of Hippo pathway which plays crucial roles in tumorigenesis.
Inhibition of Yap activity could promote apoptosis, suppress proliferation, and restrain …

Cells routinely make mistakes. Some mistakes are encoded by the genome and may
manifest as inherited or acquired diseases. Other mistakes occur because metabolic …

Abstract Poly (A)-binding protein (PABP) is a major component of the messenger RNA–
protein complex. PABP is able to bind the poly (A) tail of mRNA, as well as translation …

Prolonged sepsis and exposure to an inflammatory milieu decreases muscle protein
synthesis and reduces muscle mass. As a result of its ability to integrate diverse signals …

Over the last 10 years, the field of translational control has been enriched by atomic
resolution structures of ribosomal complexes and factors in different functional states, and …

Efficient translation initiation and optimal stability of most eukaryotic messenger RNAs
depends on the formation of a closed-loop structure and the resulting synergistic interplay …