The search for reliable indicators of biological age, rather than chronological age, has been
ongoing for over three decades, and until recently, largely without success. Advances in the …

Glycomics aims to identify the structure and function of the glycome, the complete set of
oligosaccharides (glycans), produced in a given cell or organism, as well as to identify …

Abstract The Immunoglobulin G (IgG) glycome is well known for its heterogeneity and shows
a significant degree of variation within populations. IgG glycome composition is influenced …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

In this study, we investigated the effect of five feature selection approaches on the
performance of a mixed model (G-BLUP) and a Bayesian (Bayes C) prediction method. We …

Beyond their role in neutralization, antibodies mediate functions such as phagocytosis,
cytotoxicity, and maintenance of immune homeostasis. Two modifications to the constant …

Fine structural details of glycans attached to the conserved N-glycosylation site significantly
not only affect function of individual immunoglobulin G (IgG) molecules but also mediate …

Carbohydrates possess a variety of distinct features with stereochemistry playing a
particularly important role in distinguishing their structure and function. Monosaccharide …

All immunoglobulin G molecules carry N-glycans, which modulate their biological activity.
Changes in N-glycosylation of IgG associate with various diseases and affect the activity of …

A normal hemostatic response to vascular injury requires both factor VIII (FVIII) and von
Willebrand factor (VWF). In plasma, VWF and FVIII normally circulate as a noncovalent …