More than 50% of human tumors carry TP 53 gene mutations and in consequence more
than 45,000 somatic and germline mutations have been gathered in the UMD TP 53 …

Publisher Summary The p53 protein is a tight, hydrophobic central globule containing the
DNA binding domain, flanked by accessible N-and C-terminal regions. This protein is …

Inactivation of the tumor suppressor p53 by missense mutations is the most frequent genetic
alteration in human cancers. The common missense mutations in the TP53 gene disrupt the …

We present a thorough analysis of nuclear export signals and a prediction server, which we
have made publicly available. The machine learning prediction method is a significant …

Breast cancer is the most frequent invasive tumor diagnosed in women, causing over 400
000 deaths yearly worldwide. Like other tumors, it is a disease with a complex …

The p53 tumor suppressor protein is a sequence-specific transcription factor that modulates
the response of cells to DNA damage. Recent studies suggest that full transcriptional activity …

The p53 tumor suppressor protein is involved in multiple central cellular processes,
including transcription, DNA repair, genomic stability, senescence, cell cycle control, and …

From its modest beginnings in 1979, as a transformation-associated protein, to the
discoveries that p53 plays a key role in tumour suppression and in the cellular response to …

MDM2 is an oncogene that mainly functions to modulate p53 tumor suppressor activity. In
normal cells the MDM2 protein binds to the p53 protein and maintains p53 at low levels by …

The p53 protein is a tetrameric transcription factor that plays a central role in the prevention
of neoplastic transformation. Oligomerization appears to be essential for the tumor …