Protein lipidation in cancer: mechanisms, dysregulation and emerging drug targets
EW Tate, L Soday, AL de la Lastra, M Wang… - Nature Reviews …, 2024 - nature.com
Protein lipidation describes a diverse class of post-translational modifications (PTMs) that is
regulated by over 40 enzymes, targeting more than 1,000 substrates at over 3,000 sites …
regulated by over 40 enzymes, targeting more than 1,000 substrates at over 3,000 sites …
[HTML][HTML] Emerging roles of protein palmitoylation and its modifying enzymes in cancer cell signal transduction and cancer therapy
Z Liu, M Xiao, Y Mo, H Wang, Y Han… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
Protein palmitoylation is an increasingly investigated form of post-translational lipid
modification that affects protein localization, accumulation, secretion and function. Recently …
modification that affects protein localization, accumulation, secretion and function. Recently …
Protein palmitoylation-mediated palmitic acid sensing causes blood-testis barrier damage via inducing ER stress
X Ge, Z He, C Cao, T Xue, J Jing, R Ma, W Zhao, L Liu… - Redox Biology, 2022 - Elsevier
Blood-testis barrier (BTB) damage promotes spermatogenesis dysfunction, which is a critical
cause of male infertility. Dyslipidemia has been correlated with male infertility, but the major …
cause of male infertility. Dyslipidemia has been correlated with male infertility, but the major …
Oct4A palmitoylation modulates tumorigenicity and stemness in human glioblastoma cells
X Chen, W Niu, X Fan, H Yang, C Zhao, J Fan… - Neuro …, 2023 - academic.oup.com
Background Glioblastoma multiforme and other solid malignancies are heterogeneous,
containing subpopulations of tumor cells that exhibit stem characteristics. Oct4, also known …
containing subpopulations of tumor cells that exhibit stem characteristics. Oct4, also known …
S-palmitoylation of synaptic proteins in neuronal plasticity in normal and pathological brains
Protein lipidation is a common post-translational modification of proteins that plays an
important role in human physiology and pathology. One form of protein lipidation, S …
important role in human physiology and pathology. One form of protein lipidation, S …
2-Bromopalmitate decreases spinal inflammation and attenuates oxaliplatin-induced neuropathic pain via reducing Drp1-mediated mitochondrial dysfunction
ZB Dong, YJ Wang, ML Cheng, BJ Wang, H Lu, HL Zhu… - Plos one, 2022 - journals.plos.org
Oxaliplatin (OXA) is a third-generation platinum compound with clinical activity in multiple
solid tumors. Due to the repetition of chemotherapy cycle, OXA-induced chronic neuropathy …
solid tumors. Due to the repetition of chemotherapy cycle, OXA-induced chronic neuropathy …
Development of a novel high-throughput screen for the identification of new inhibitors of protein S-acylation
C Salaun, H Takizawa, A Galindo, KR Munro… - Journal of Biological …, 2022 - ASBMB
Protein S-acylation is a reversible post-translational modification that modulates the
localization and function of many cellular proteins. S-acylation is mediated by a family of zinc …
localization and function of many cellular proteins. S-acylation is mediated by a family of zinc …
Palmitoylation regulates human serotonin transporter activity, trafficking, and expression and is modulated by escitalopram
CR Brown, JD Foster - ACS Chemical Neuroscience, 2023 - ACS Publications
In the central nervous system, serotonergic signaling modulates sleep, mood, and cognitive
control. During serotonergic transmission, the synaptic concentration of serotonin is tightly …
control. During serotonergic transmission, the synaptic concentration of serotonin is tightly …
MAVS Cys508 palmitoylation promotes its aggregation on the mitochondrial outer membrane and antiviral innate immunity
Cysteine palmitoylation or S-palmitoylation catalyzed by the ZDHHC family of
acyltransferases regulates the biological function of numerous mammalian proteins as well …
acyltransferases regulates the biological function of numerous mammalian proteins as well …
Inhibition of palmitoyltransferase ZDHHC12 sensitizes ovarian cancer cells to cisplatin through ROS‐mediated mechanisms
X Zhang, X Liao, M Wang, J Liu, J Han, D An… - Cancer …, 2024 - Wiley Online Library
Platinum‐based therapies have revolutionized the treatment of high‐grade serous ovarian
cancer (HGSOC). However, high rates of disease recurrence and progression remain a …
cancer (HGSOC). However, high rates of disease recurrence and progression remain a …