Protein lipidation describes a diverse class of post-translational modifications (PTMs) that is
regulated by over 40 enzymes, targeting more than 1,000 substrates at over 3,000 sites …

Protein palmitoylation is an increasingly investigated form of post-translational lipid
modification that affects protein localization, accumulation, secretion and function. Recently …

Blood-testis barrier (BTB) damage promotes spermatogenesis dysfunction, which is a critical
cause of male infertility. Dyslipidemia has been correlated with male infertility, but the major …

Background Glioblastoma multiforme and other solid malignancies are heterogeneous,
containing subpopulations of tumor cells that exhibit stem characteristics. Oct4, also known …

Protein lipidation is a common post-translational modification of proteins that plays an
important role in human physiology and pathology. One form of protein lipidation, S …

Oxaliplatin (OXA) is a third-generation platinum compound with clinical activity in multiple
solid tumors. Due to the repetition of chemotherapy cycle, OXA-induced chronic neuropathy …

Protein S-acylation is a reversible post-translational modification that modulates the
localization and function of many cellular proteins. S-acylation is mediated by a family of zinc …

In the central nervous system, serotonergic signaling modulates sleep, mood, and cognitive
control. During serotonergic transmission, the synaptic concentration of serotonin is tightly …

Cysteine palmitoylation or S-palmitoylation catalyzed by the ZDHHC family of
acyltransferases regulates the biological function of numerous mammalian proteins as well …

Platinum‐based therapies have revolutionized the treatment of high‐grade serous ovarian
cancer (HGSOC). However, high rates of disease recurrence and progression remain a …