As an emerging cancer therapeutic target, non-apoptotic cell death such as ferroptosis,
necroptosis and pyroptosis, etc., has revealed significant potential in cancer treatment for …

Standard anti-cancer therapies promote tumor growth suppression mainly via induction of
apoptosis. However, in most cases cancer cells acquire the ability to escape apoptotic cell …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Plumbagin (PLB), a natural naphthoquinone constituent isolated from the roots of the
medicinal plant Plumbago zeylanica L., exhibited anticancer activity against a variety of …

Programmed cell death (PCD) is the universal process that maintains cellular homeostasis
and regulates all living systems' development, health and disease. Out of all, apoptosis is …

Due to the sustained proliferative potential of cancer cells, inducing cell death is a potential
strategy for cancer therapy. Paraptosis is a mode of cell death characterized by endoplasmic …

Abstract Auranofin (AF), a gold (I)-containing phosphine compound, is being investigated for
oncological application as a repurposed drug. We show here that 4~ 5 µM AF induces …

Paraptosis is a type of programmed cell death that is characterized by dilation of the
endoplasmic reticulum (ER) and/or mitochondria. Since paraptosis is morphologically and …

Immunotherapy holds significant promise for cancer treatment. However, the highly
immunosuppressive nature of solid tumors limits its effectiveness. Herein, we developed …

Cell death plays a critical role in organism development and the pathogenesis of diseases.
Necrosis is considered a non-programmed cell death in an extreme environment. Recent …