One of the original hypotheses of organismal longevity posits that aging is the natural result
of entropy on the cells, tissues, and organs of the animal—a slow, inexorable slide into …

Most non-communicable diseases involve inflammatory changes in one or more vascular
systems, and there is considerable evidence that unliganded iron plays major roles in this …

Red blood cells (RBCs) are highly deformable and possess a robust membrane that can
withstand shear force. Previous research showed that in diabetic patients, there is a …

The atomic force microscope is a widely used surface scanning apparatus capable of
reconstructing at a nanometric scale resolution the 3D morphology of biological samples …

The roughness of cell membrane is a very interesting indicator of cell's health state. Atomic
Force Microscopy allows us to investigate the roughness of cell membrane in great detail …

In order to pass through the microcirculation, red blood cells (RBCs) need to undergo
extensive deformations and to recover the original shape. This extreme deformability is …

Summary Background: Red blood cells (RBCs) undergo a natural aging process occurring
in the blood circulation throughout the RBC lifespan or during routine cold storage in the …

Atomic force microscopy (AFM) offers complementary imaging modes that can provide
morphological and structural details of red blood cells (RBCs), and characterize interactions …

During their lifespan, Red blood cells (RBC), due to their inability to self-replicate, undergo
an ageing degradation phenomenon. This pathway, both in vitro and in vivo, consists of a …

Cancer remains a major cause of morbidity and mortality worldwide. Although progress has
been made regarding chemotherapeutic agents, new therapies that combine increased …