RASSF1A (Ras association domain family 1 isoform A) is a recently discovered tumor
suppressor whose inactivation is implicated in the development of many human cancers …

In recent years, the list of tumor suppressor genes (or candidate TSG) that are inactivated
frequently by epigenetic events rather than classic mutation/deletion events has been …

Ras proteins play a direct causal role in human cancer with activating mutations in Ras
occurring in∼ 30% of tumours. Ras effectors also contribute to cancer, as mutations occur in …

Papillary and invasive cancers of the urinary bladder appear to evolve and progress through
distinct molecular pathways. Invasion in bladder cancer forebodes a graver prognosis, and …

Tumour suppressor gene inactivation is critical to the pathogenesis of cancers; such loss of
function may be mediated by irreversible processes such as gene deletion or mutation …

The human Ras association domain family 1 (RASSF1) gene is located at 3p21. 3 in an area
that is believed to harbor at least one important tumor suppressor gene. The two major …

Purpose: There is increasing evidence for a fundamental role for epigenetic silencing of
apoptotic pathways in cancer. Changes in DNA methylation can be detected with a high …

Inorganic arsenic (iAs) is an environmental toxicant currently poisoning millions of people
worldwide, and chronically exposed individuals are susceptible to arsenicosis or arsenic …

Tobacco smoking, certain occupational exposures, and exposure to inorganic arsenic in
drinking water have been associated with the occurrence of bladder cancer. However, in …

The RAS association domain family 1A (RASSF1A) gene is silenced by DNA methylation in
over 50% of all solid tumors of different histological types. However, the biochemical function …