The hallmarks of flavonoids in cancer

LGS Ponte, ICB Pavan, MCS Mancini, LGS da Silva… - Molecules, 2021 - mdpi.com
Flavonoids represent an important group of bioactive compounds derived from plant-based
foods and beverages with known biological activity in cells. From the modulation of …

Ferroptosis‐modulating small molecules for targeting drug‐resistant cancer: Challenges and opportunities in manipulating redox signaling

SC Koeberle, AP Kipp, H Stuppner… - Medicinal Research …, 2023 - Wiley Online Library
Ferroptosis is an iron‐dependent cell death program that is characterized by excessive lipid
peroxidation. Triggering ferroptosis has been proposed as a promising strategy to fight …

Targeting regulated cell death with pharmacological small molecules: An update on autophagy-dependent cell death, ferroptosis, and necroptosis in cancer …

J Wu, J Ye, Q Xie, B Liu, M Liu - Journal of Medicinal Chemistry, 2022 - ACS Publications
Regulated cell death is a widely attractive subject among the topics of cancer therapy and
has gained some advances for discovery of targeted anticancer drugs. In the past decade …

Therapeutic influence on important targets associated with chronic inflammation and oxidative stress in cancer treatment

M Neganova, J Liu, Y Aleksandrova, S Klochkov, R Fan - Cancers, 2021 - mdpi.com
Simple Summary There is no doubt that the need for new effective methods of cancer
treatment remains challenging, as cancer is the second cause of death based on the …

Apigenin role as cell-signaling pathways modulator: implications in cancer prevention and treatment

Z Javed, H Sadia, MJ Iqbal, S Shamas, K Malik… - Cancer Cell …, 2021 - Springer
Cancer is a complex disease orchestrated by various extrinsic and intrinsic pathways. In
recent years, there has been a keen interest towards the development of natural extracts …

Apigenin in cancer therapy: Prevention of genomic instability and anticancer mechanisms

M Moslehi, S Rezaei, P Talebzadeh… - Clinical and …, 2023 - Wiley Online Library
The incidence of cancer has been growing worldwide. Better survival rates following the
administration of novel drugs and new combination therapies may concomitantly cause …

Ferroptosis regulation by methylation in cancer

M Hao, Y Jiang, Y Zhang, X Yang, J Han - Biochimica et Biophysica Acta …, 2023 - Elsevier
Epigenetic regulation plays a critical role in cancer development and progression.
Methylation is an important epigenetic modification that influences gene expression by …

The multifaceted role of flavonoids in cancer therapy: leveraging autophagy with a double-edged sword

Z Zhang, J Shi, EC Nice, C Huang, Z Shi - Antioxidants, 2021 - mdpi.com
Flavonoids are considered as pleiotropic, safe, and readily obtainable molecules. A large
number of recent studies have proposed that flavonoids have potential in the treatment of …

Role of induced programmed cell death in the chemopreventive potential of apigenin

JY Jang, B Sung, ND Kim - International Journal of Molecular Sciences, 2022 - mdpi.com
The flavonoid apigenin (4′, 5, 7-trihydroxyflavone), which is one of the most widely
distributed phytochemicals in the plant kingdom, is one of the most thoroughly investigated …

Review and chemoinformatic analysis of ferroptosis modulators with a focus on natural plant products

V Stepanić, M Kučerová-Chlupáčová - Molecules, 2023 - mdpi.com
Ferroptosis is a regular cell death pathway that has been proposed as a suitable therapeutic
target in cancer and neurodegenerative diseases. Since its definition in 2012, a few hundred …