Purpose The autonomic nervous system, consisting of sympathetic and
parasympathetic/vagal nerves, is known to control the functions of any organ, maintaining …

The effects of autonomic innervation of tumors on tumor growth remain unclear. Here we
developed a series of genetic techniques to manipulate autonomic innervation in a tumor …

Voltage-gated sodium channel β1 and β2 subunits were discovered as auxiliary proteins
that co-purify with pore-forming α subunits in brain. The other family members, β1B, β3, and …

Although nutrient-starvation therapies can elicit strong anti-tumor effects in multiple
carcinomas, it has been convincingly demonstrated that cancer cells exploit the tumor …

Voltage-gated sodium (NaV) channels initiate electrical signalling in excitable cells and are
the molecular targets for drugs and disease mutations, but the structural basis for their …

In excitable cells, voltage-gated sodium (NaV) channels activate to initiate action potentials
and then undergo fast and slow inactivation processes that terminate their ionic …

Voltage-gated sodium channels are vital membrane proteins essential for electrical
signalling; in humans, they are key targets for the development of pharmaceutical drugs …

The crystal structure of the open conformation of a bacterial voltage-gated sodium channel
pore from Magnetococcus sp.(NaVMs) has provided the basis for a molecular dynamics …

Voltage-gated sodium channels (Na V s) are central elements of cellular excitation.
Notwithstanding advances from recent bacterial Na V (BacNa V) structures, key questions …

Voltage‐gated sodium channels are essential for electrical signalling across cell
membranes. They exhibit strong selectivities for sodium ions over other cations, enabling the …