Intracerebral hemorrhage (ICH) is a devastating form of stroke with high morbidity and
mortality. This review article focuses on the epidemiology, cause, mechanisms of injury …

NLRP3 is the best characterized cytosolic nod-like pattern recognition receptor which can
detect microbial motifs, endogenous danger and stress signals. Activation of NLRP3 leads to …

Neuroinflammation and neurodegeneration often result from the aberrant deposition of
aggregated host proteins, including amyloid‐β, α‐synuclein, and prions, that can activate …

Background Traumatic brain injury (TBI) is a leading cause of death and disability
worldwide. Microglial/macrophage activation and neuroinflammation are key cellular events …

The NLRP3 inflammasome is a multiprotein platform which is activated upon cellular
infection or stress. Its activation leads to caspase-1-dependent secretion of proinflammatory …

Stroke is the leading cause of adult disability and mortality in most developing and
developed countries. The current best practices for patients with acute ischemic stroke …

Microglia/macrophages are the major immune cells involved in the defence against brain
damage. Their morphology and functional changes are correlated with the release of danger …

Neuroinflammation has been identified as a causative factor of multiple neurological
diseases. The nucleotide-binding oligomerization domain-, leucine-rich repeat-and pyrin …

Diffuse white-matter disease associated with small-vessel disease and dementia is
prevalent in the elderly. The biological mechanisms, however, remain elusive. Using …

Abstract Background α-Synuclein (α-Syn), a pathological hallmark of Parkinson's disease
(PD), has been recognized to induce the production of interleukin-1β in a process that …