15 years of GWAS discovery: realizing the promise
It has been 15 years since the advent of the genome-wide association study (GWAS) era.
Here, we review how this experimental design has realized its promise by facilitating an …
Here, we review how this experimental design has realized its promise by facilitating an …
Challenges and opportunities for developing more generalizable polygenic risk scores
Polygenic risk scores (PRS) estimate an individual's genetic likelihood of complex traits and
diseases by aggregating information across multiple genetic variants identified from genome …
diseases by aggregating information across multiple genetic variants identified from genome …
Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects
Estimates from genome-wide association studies (GWAS) of unrelated individuals capture
effects of inherited variation (direct effects), demography (population stratification …
effects of inherited variation (direct effects), demography (population stratification …
Gene–environment correlations across geographic regions affect genome-wide association studies
Gene–environment correlations affect associations between genetic variants and complex
traits in genome-wide association studies (GWASs). Here we showed in up to 43,516 British …
traits in genome-wide association studies (GWASs). Here we showed in up to 43,516 British …
[PDF][PDF] Mating Order Establishes Male Size Advantage in the Polygynandrous Millipede Centrobolus inscriptus Attems, 1928
M Cooper - New Visions in Biological Science, 2022 - researchgate.net
ABSTRACT A forest species of millipede belonging to the Order Spirobolida found along the
eastern coast of southern Africa were tested for size assortative mating. The objectives …
eastern coast of southern Africa were tested for size assortative mating. The objectives …
[HTML][HTML] Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses
Estimates from Mendelian randomization studies of unrelated individuals can be biased due
to uncontrolled confounding from familial effects. Here we describe methods for within-family …
to uncontrolled confounding from familial effects. Here we describe methods for within-family …
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
Here we conducted a large-scale genetic association analysis of educational attainment in a
sample of approximately 1.1 million individuals and identify 1,271 independent genome …
sample of approximately 1.1 million individuals and identify 1,271 independent genome …
Effects of urban living environments on mental health in adults
J Xu, N Liu, E Polemiti, L Garcia-Mondragon, J Tang… - Nature medicine, 2023 - nature.com
Urban-living individuals are exposed to many environmental factors that may combine and
interact to influence mental health. While individual factors of an urban environment have …
interact to influence mental health. While individual factors of an urban environment have …
The nature of nurture: Effects of parental genotypes
Sequence variants in the parental genomes that are not transmitted to a child (the proband)
are often ignored in genetic studies. Here we show that nontransmitted alleles can affect a …
are often ignored in genetic studies. Here we show that nontransmitted alleles can affect a …
Improved polygenic prediction by Bayesian multiple regression on summary statistics
Accurate prediction of an individual's phenotype from their DNA sequence is one of the great
promises of genomics and precision medicine. We extend a powerful individual-level data …
promises of genomics and precision medicine. We extend a powerful individual-level data …