The Notch signaling pathway is conserved from Drosophila to mammals and is critically
involved in developmental processes. In the immune system, it has been established that …

Differentiation of naïve T cells into effector cells is required for optimal protection against
different classes of microbial pathogen and for the development of immune memory. Recent …

From January 2020, coronavirus disease (COVID-19) originated in China has spread
around the world. The disease is caused by the severe acute respiratory syndrome …

Diabetic nephropathy (DN) is one of the main causes of end-stage renal disease (ESRD).
Existing treatments cannot control the progression of diabetic nephropathy very well. In …

Notch signaling, a highly conserved pathway in mammals, is crucial for differentiation and
homeostasis of immune cells. Besides, this pathway is also directly involved in the …

Notch signaling coordinates numerous cellular processes and has been implicated in many
pathological conditions, including rheumatoid arthritis (RA). Although the role of Notch …

Influenza viruses pose a substantial threat to human and animal health worldwide. Recent
studies in mouse models have revealed an indispensable role for the innate immune system …

Cancer immunosurveillance is critical for the elimination of neoplastic cells. In addition,
recent advances in immunological checkpoint blockade drugs have revealed the importance …

Overproduction of inflammatory cytokines is a keystone event in COVID-19 pathogenesis;
TNF and its receptors (TNFR1 and TNFR2) are critical pro-inflammatory molecules. ADAM17 …

The evolutionarily conserved Notch signalling pathway regulates the differentiation and
function of mature T lymphocytes with major context-dependent consequences in host …