Intercellular tight junctions represent a formidable barrier against paracellular drug
absorption at epithelia (eg, nasal, intestinal) and the endothelium (eg, blood–brain barrier) …

Human epidermal growth factor receptor 2 (HER2) overexpression and amplification have
been reported as predictive markers for HER2-targeted therapy in breast and gastric cancer …

Trastuzumab deruxtecan (DS-8201) is an antibody–drug conjugate composed of a
humanized monoclonal anti-HER2 antibody, a cleavable tetrapeptide-based linker and a …

Despite significant improvement in modalities for treatment of cancer that led to a longer
survival period, the death rate of patients with solid tumors has not changed during the last …

Kinins are generated within inflammatory tissue microenvironments, where they exert
diverse functions, including cell proliferation, leukocyte activation, cell migration, endothelial …

BACKGROUND: The HER2/neu gene is a proto-oncogene that can predict the response to
treatment with trastuzumab, pertuzumab, and lapatinib. This study was conducted to …

Introduction: Kinins are peptide mediators exerting their pro-inflammatory actions by the
selective stimulation of two distinct G-protein coupled receptors, termed BKB1R and BKB2R …

Gallbladder cancer, although regarded as the most common malignancy of the biliary tract,
continues to be associated with a dismal overall survival even in the present day. While …

Gallbladder cancer is the most common and aggressive malignancy of the biliary tract. The
complete surgical resection is the only potentially curative approach in early stage; however …

Kinins are bioactive peptides generated in the inflammatory milieu of the tissue
microenvironment, which is involved in cancer progression and inflammatory response …