The molecular mechanisms that finely co‐ordinate fibrin formation and fibrinolysis are now
well defined. The structure and function of all major fibrinolytic proteins, which include serine …

Annexin A2 is a pleiotropic calcium-and anionic phospholipid-binding protein that exists as
a monomer and as a heterotetrameric complex with the plasminogen receptor protein …

Fibrinolysis is regulated by specific molecular interactions between its main components.
Activation of plasminogen by tissue-type plasminogen activator (t-PA) is enhanced in the …

α‐enolase (ENOA) is a metabolic enzyme involved in the synthesis of pyruvate. It also acts
as a plasminogen receptor and thus mediates activation of plasmin and extracellular matrix …

Many advanced tumors overexpress and secrete the S100A4 protein that is known to
promote angiogenesis and metastasis development. The mechanisms of this effect and the …

Cathepsin B is a lysosomal cysteine protease in normal cells and tissues. In malignant
tumors and premalignant lesions, the expression of cathepsin B is highly upregulated and …

Patients with antiphospholipid antibodies (APLAs) are at increased risk for arterial and
venous thrombosis. Many APLAs associated with these events react with β2 glycoprotein I …

β 2-Glycoprotein I (β 2 GPI) is an abundant plasma phospholipid-binding protein and an
autoantigen in the antiphospholipid antibody syndrome. Binding of β 2 GPI to endothelial …

The cysteine protease cathepsin B is upregulated in a variety of tumors, particularly at the
invasive edges. Cathepsin B can degrade extracellular matrix proteins, such as collagen IV …

Objective: To determine the characteristics of trauma patients with low levels of fibrinolysis
as detected by viscoelastic hemostatic assay (VHA) and explore the underlying mechanisms …