What makes a good new therapeutic l-asparaginase?
Abstract l-asparaginase is a critical part of the treatment of acute lymphoblastic leukaemia in
children and adolescents, and has contributed to the improvement in patient outcomes over …
children and adolescents, and has contributed to the improvement in patient outcomes over …
Exploring current scenario and developments in the field of microbial L-asparaginase production and applications: A review
PG Patel, HZ Panseriya, AK Vala, BP Dave… - Process …, 2022 - Elsevier
L-asparaginase, an amidohydrolase that catalyses break down of L-asparagine into aspartic
acid and ammonia, is one of the most prominent biopharmaceuticals. L-asparaginase (LA) …
acid and ammonia, is one of the most prominent biopharmaceuticals. L-asparaginase (LA) …
Purification, characterization and immunogenicity assessment of glutaminase free L-asparaginase from Streptomyces brollosae NEAE-115
NEA El-Naggar, SF Deraz, SM El-Ewasy… - BMC Pharmacology and …, 2018 - Springer
Background L-asparaginase is a potential therapeutic enzyme widely used in the
chemotherapy protocols of pediatric and adult patients with acute lymphoblastic leukemia …
chemotherapy protocols of pediatric and adult patients with acute lymphoblastic leukemia …
Characterization of L-asparaginase from marine-derived Aspergillus niger AKV-MKBU, its antiproliferative activity and bench scale production using industrial waste
AK Vala, B Sachaniya, D Dudhagara… - International journal of …, 2018 - Elsevier
Abstract L-asparaginase (LA), an enzyme with anticancer activities, produced by marine-
derived Aspergillus niger was subjected to purification and characterization. The purified …
derived Aspergillus niger was subjected to purification and characterization. The purified …
Biochemical characterization of extremozyme L-asparaginase from Pseudomonas sp. PCH199 for therapeutics
Abstract L-asparaginase (L-ASNase) from microbial sources is a commercially vital enzyme
to treat acute lymphoblastic leukemia. However, the side effects associated with the …
to treat acute lymphoblastic leukemia. However, the side effects associated with the …
L-asparaginase immobilization in supramolecular nanogels of PEG-grafted poly HPMA and bis (α-cyclodextrin) to enhance pharmacokinetics and lower enzyme …
L-asparaginase (ASNase) enzyme has limited therapeutic use due to its poor
pharmacokinetics and immunogenicity. To overcome these obstacles, we immobilized …
pharmacokinetics and immunogenicity. To overcome these obstacles, we immobilized …
Critical overview of the main features and techniques used for the evaluation of the clinical applicability of L-asparaginase as a biopharmaceutical to treat blood …
TA Costa-Silva, IM Costa, HP Biasoto, GM Lima… - Blood Reviews, 2020 - Elsevier
L-asparaginase is an enzyme used as a biopharmaceutical to treat acute lymphoblastic
leukemia. Several adverse effects have been related to L-asparaginase use, so the scientific …
leukemia. Several adverse effects have been related to L-asparaginase use, so the scientific …
Colorectal cancer treatment using bacteria: focus on molecular mechanisms
S Ebrahimzadeh, H Ahangari, A Soleimanian… - BMC microbiology, 2021 - Springer
Background Colorectal cancer which is related to genetic and environmental risk factors, is
among the most prevalent life-threatening cancers. Although several pathogenic bacteria …
among the most prevalent life-threatening cancers. Although several pathogenic bacteria …
Co-delivery of docetaxel and curcumin prodrug via dual-targeted nanoparticles with synergistic antitumor activity against prostate cancer
J Yan, Y Wang, Y Jia, S Liu, C Tian, W Pan… - Biomedicine & …, 2017 - Elsevier
Purpose Combination therapy is increasingly used as a primary cancer treatment regimen.
In this report, we designed EGFR peptide decorated nanoparticles (NPs) to co-deliver …
In this report, we designed EGFR peptide decorated nanoparticles (NPs) to co-deliver …
Molecular cloning, structural modeling and characterization of a novel glutaminase-free L-asparaginase from Cobetia amphilecti AMI6
MG Farahat, D Amr, A Galal - International journal of biological …, 2020 - Elsevier
The exploration of new sources of L-asparaginase with low glutaminase activity is of great
interest in both medical and food applications. In the current study, a novel L-asparaginase …
interest in both medical and food applications. In the current study, a novel L-asparaginase …