Due to the inability of current clinical practices to restore function to degenerated
intervertebral discs, the arena of disc tissue engineering has received substantial attention …

Low back pain (LBP), commonly induced by intervertebral disc degeneration, is a lumbar
disease with worldwide prevalence. However, the mechanism of degeneration remains …

In articular cartilage, chondrocytes are surrounded by a narrow region called the pericellular
matrix (PCM), which is biochemically, structurally, and mechanically distinct from the bulk …

Intervertebral disc degeneration (IDD) is a major contributing factor to both lower back and
neck pain. As IDD progresses, the intervertebral disc (IVD) loses its ability to maintain its disc …

The pericellular matrix (PCM) is a narrow region that is rich in type VI collagen that
surrounds each chondrocyte within the extracellular matrix (ECM) of articular cartilage …

Although tissue engineering has attracted increasing attention for the treatment of
degenerative intervertebral disc disease, the biochemical properties, structural organization …

An emerging application of nanotechnology in medicine currently being developed involves
employing nanoparticles to deliver drugs, heat, light, or other substances to specific types of …

Measurements related to nano-and micro-scale science, technology, and manufacturing are
pushing the limits of detectable mechanical, electrical, and chemical quantities to ever …

Intervertebral disc degeneration is a leading cause of disability in the elderly population.
Rigid extracellular matrix is a critical pathological feature of disc degeneration, leading to …

Purpose To investigate the regional tensile properties of human annulus fibrosus (AF) and
relate them to magnetic resonance imaging (MRI) findings. Methods 44 human cadaveric …