Background and Objectives: Ketamine is a rapid-acting antidepressant with proven efficacy
as an add-on agent in unipolar and bipolar treatment-resistant depression. Although many …

Millions of individuals worldwide suffers from mood disorders, especially major depressive
disorder (MDD), which has a high rate of disease burden in society. Although targeting the …

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder. Maternal
separation (MS) stress is an established model of early-life stress associated with autistic …

The purpose of this study was to develop lamotrigine nanoliposomes (LTG-NLs) for the
treatment in seizures. The formulation was prepared using thin film hydration and …

Diabetes mellitus often results in a number of complications involving impaired brain
function, including cognitive deficits and depression. However, the potential mechanisms for …

The ability of the N-methyl-d-aspartate receptor antagonist ketamine to induce a rapid and
sustained antidepressant effect has led to a surge in pre-clinical studies investigating …

Flavonoids are phenolic compounds found commonly in plants that protect them against the
negative effects of environmental insults. These secondary metabolites have been widely …

Objective: Augmentation strategies are commonly applied when an individual is
unresponsive to antidepressant monotherapy. Lamotrigine is currently considered at best …

Background Experiencing early-life stress plays an important role in the pathophysiology of
anxiety disorders. Ferulic acid is a phenolic compound found in some plants which has …

Lamotrigine (LTG) is a second-generation antiepileptic drug that belongs to
Biopharmaceutics Classification System (BCS) class II. LTG has a low probability of crossing …