In recent decades, there have been several models describing the relationships between
the cytoskeleton and the bioenergetic function of the cell. The main player in these models is …

Mitochondria serve several important roles in maintaining cellular homeostasis, including
adenosine triphosphate (ATP) synthesis, apoptotic signalling, and regulation of both reactive …

Acute myeloid leukemia (AML) is an aggressive hematological malignancy. Nearly 50% of
patients who receive the most intensive treatment inevitably experience disease relapse …

This study aimed to characterize the ATP-synthesis by oxidative phosphorylation in
colorectal cancer (CRC) and premalignant colon polyps in relation to molecular biomarkers …

In colorectal cancer (CRC) energy metabolism research, the precancerous stage of polyp
has remained rather unexplored. By now, it has been shown that CRC has not fully obtained …

Metabolic plasticity is the ability of the cell to adjust its metabolism to changes in
environmental conditions. Increased metabolic plasticity is a defining characteristic of cancer …

Ample sperm production is essential for successful male reproduction in many species. The
amount of sperm a male can produce is typically constrained by the size of his testes, which …

Nonketotic hyperglycinemia (NKH) is an inherited disorder of amino acid metabolism
biochemically characterized by the accumulation of glycine (Gly) predominantly in the brain …

Ethylmalonic encephalopathy (EE) is a severe inherited metabolic disorder that causes
tissue accumulation of hydrogen sulfide (sulfide) and thiosulfate in patients. Although …

The protein wolframin is localized in the membrane of the endoplasmic reticulum (ER),
influencing Ca2+ metabolism and ER interaction with mitochondria, but the exact role of the …