A comprehensive review on MAPK: a promising therapeutic target in cancer
The mitogen-activated protein kinase (MAPK) pathway is an important bridge in the switch
from extracellular signals to intracellular responses. Alterations of signaling cascades are …
from extracellular signals to intracellular responses. Alterations of signaling cascades are …
Mini review: The FDA-approved prescription drugs that target the MAPK signaling pathway in women with breast cancer
Breast cancer (BC) is the most common cancer and the prevalent type of malignancy among
women. Multiple risk factors, including genetic changes, biological age, dense breast tissue …
women. Multiple risk factors, including genetic changes, biological age, dense breast tissue …
HB‐EGF‐loaded nanovesicles enhance trophectodermal spheroid attachment and invasion
The ability of trophectodermal cells (outer layer of the embryo) to attach to the endometrial
cells and subsequently invade the underlying matrix are critical stages of embryo …
cells and subsequently invade the underlying matrix are critical stages of embryo …
Reconstructing static and dynamic models of signaling pathways using Modular Response Analysis
In this review we discuss the origination and evolution of Modular Response Analysis
(MRA), which is a physics-based method for reconstructing quantitative topological models …
(MRA), which is a physics-based method for reconstructing quantitative topological models …
Impact of measurement noise, experimental design, and estimation methods on Modular Response Analysis based network reconstruction
Abstract Modular Response Analysis (MRA) is a method to reconstruct signalling networks
from steady-state perturbation data which has frequently been used in different settings …
from steady-state perturbation data which has frequently been used in different settings …
miR‑9 depletion suppresses the proliferation of osteosarcoma cells by targeting p16
S Gao, J Wang, S Tian, J Luo - … Journal of Oncology, 2019 - spandidos-publications.com
Osteosarcoma (OS) is a common primary malignancy in adolescents and children.
MicroRNAs (miRNAs or miRs) can regulate the progression of OS. Herein, we explored the …
MicroRNAs (miRNAs or miRs) can regulate the progression of OS. Herein, we explored the …
Synthesis and In Vitro Evaluation of Tetrahydroquinoline Derivatives as Anti-proliferative Compounds of Breast Cancer via Targeting the GPER
OJ Zacarías-Lara, D Méndez-Luna… - Anti-Cancer Agents …, 2019 - ingentaconnect.com
Background: Some reports have demonstrated the role of the G Protein-coupled Estrogen
Receptor (GPER) in growth and proliferation of breast cancer cells. Objective: In an effort to …
Receptor (GPER) in growth and proliferation of breast cancer cells. Objective: In an effort to …
[HTML][HTML] STAT3 knockdown induces tumor formation by MDA-MB-231 cells
K Banerjee, C Pru, JK Pru, H Resat - Clinical oncology and …, 2018 - ncbi.nlm.nih.gov
STAT3 plays a central role in oncogenesis by mediating cell survival, growth, and
differentiation. It is constitutively activated in breast cancer. We investigated the role of …
differentiation. It is constitutively activated in breast cancer. We investigated the role of …
Mapping connections in signaling networks with ambiguous modularity
D Lill, OS Rukhlenko, AJ Mc Elwee… - NPJ Systems Biology …, 2019 - nature.com
Abstract Modular Response Analysis (MRA) is a suite of methods that under certain
assumptions permits the precise reconstruction of both the directions and strengths of …
assumptions permits the precise reconstruction of both the directions and strengths of …
Interactions between ligand-bound EGFR and VEGFR2
MD Paul, K Hristova - Journal of molecular biology, 2021 - Elsevier
In this work, we put forward the provocative hypothesis that the active, ligand-bound RTK
dimers from unrelated subfamilies can associate into heterooligomers with novel signaling …
dimers from unrelated subfamilies can associate into heterooligomers with novel signaling …