Obesity remains the most important risk factor for the incidence and progression of
osteoarthritis (OA). The leading cause of OA was believed to be overloading the joints due to …

Osteoarthritis is a highly prevalent disease particularly in subjects over 65 years of age
worldwide. While in the past it was considered a mere consequence of cartilage degradation …

Osteoarthritis (OA) is a chronic disease and the most common orthopedic disorder. A vast
majority of the social OA burden is related to hips and knees. The prevalence of knee OA …

The ability of articular cartilage to repair itself is limited because it lacks blood vessels,
nerves, and lymph tissue. Once damaged, it can lead to joint swelling and pain, accelerating …

Being the most common musculoskeletal progressive condition, osteoarthritis is an
interesting target for research. It is estimated that the prevalence of knee osteoarthritis (OA) …

Osteoarthritis (OA) is a type of joint disease associated with wear and tear, inflammation,
and aging. Mechanical stress along with synovial inflammation promotes the degradation of …

We elucidated the molecular cross-talk between cartilage and synovium in osteoarthritis, the
most widespread arthritis in the world, using the powerful tool of single-cell RNA …

Cartilage degeneration is among the fundamental reasons behind disability and pain across
the globe. Numerous approaches have been employed to treat cartilage diseases …

Modern concepts of osteoarthritis (OA) have been forever changed by modern imaging
phenotypes demonstrating complex and multi-tissue pathologies involving cartilage …

Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but
accumulating evidence indicates that inflammation has a critical role in its pathogenesis …