Cancer cell plasticity during tumor progression, metastasis and response to therapy
A Pérez-González, K Bévant, C Blanpain - Nature cancer, 2023 - nature.com
Cell plasticity represents the ability of cells to be reprogrammed and to change their fate and
identity, enabling homeostasis restoration and tissue regeneration following damage. Cell …
identity, enabling homeostasis restoration and tissue regeneration following damage. Cell …
Copper metabolism in cell death and autophagy
Copper is an essential trace element in biological systems, maintaining the activity of
enzymes and the function of transcription factors. However, at high concentrations, copper …
enzymes and the function of transcription factors. However, at high concentrations, copper …
[HTML][HTML] Claudin18. 2-specific CAR T cells in gastrointestinal cancers: phase 1 trial interim results
C Qi, J Gong, J Li, D Liu, Y Qin, S Ge, M Zhang… - Nature medicine, 2022 - nature.com
Despite success in hematologic malignancies, the treatment landscape of chimeric antigen
receptor (CAR) T cell therapy for solid tumors remains limited. Claudin18. 2 (CLDN18. 2) …
receptor (CAR) T cell therapy for solid tumors remains limited. Claudin18. 2 (CLDN18. 2) …
[HTML][HTML] Regulation of PD-L1 expression in the tumor microenvironment
M Yi, M Niu, L Xu, S Luo, K Wu - Journal of hematology & oncology, 2021 - Springer
Abstract Programmed death-ligand 1 (PD-L1) on cancer cells engages with programmed
cell death-1 (PD-1) on immune cells, contributing to cancer immune escape. For multiple …
cell death-1 (PD-1) on immune cells, contributing to cancer immune escape. For multiple …
[HTML][HTML] Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape
Q Wu, L You, E Nepovimova, Z Heger, W Wu… - Journal of hematology & …, 2022 - Springer
Hypoxia, a common feature of the tumor microenvironment in various types of cancers,
weakens cytotoxic T cell function and causes recruitment of regulatory T cells, thereby …
weakens cytotoxic T cell function and causes recruitment of regulatory T cells, thereby …
[HTML][HTML] The role of microenvironment in tumor angiogenesis
X Jiang, J Wang, X Deng, F Xiong, S Zhang… - Journal of Experimental …, 2020 - Springer
Tumor angiogenesis is necessary for the continued survival and development of tumor cells,
and plays an important role in their growth, invasion, and metastasis. The tumor …
and plays an important role in their growth, invasion, and metastasis. The tumor …
[HTML][HTML] VEGF/VEGFR-targeted therapy and immunotherapy in non-small cell lung cancer: targeting the tumor microenvironment
Non-small cell lung cancer (NSCLC) is the leading cause of death by cancer worldwide.
Despite developments in therapeutic approaches for the past few decades, the 5-year …
Despite developments in therapeutic approaches for the past few decades, the 5-year …
[HTML][HTML] Single‐cell RNA sequencing in cancer research
Y Zhang, D Wang, M Peng, L Tang, J Ouyang… - Journal of Experimental …, 2021 - Springer
Single-cell RNA sequencing (scRNA-seq), a technology that analyzes transcriptomes of
complex tissues at single-cell levels, can identify differential gene expression and epigenetic …
complex tissues at single-cell levels, can identify differential gene expression and epigenetic …
Role of tumor microenvironment in cancer progression and therapeutic strategy
Q Wang, X Shao, Y Zhang, M Zhu, FXC Wang… - Cancer …, 2023 - Wiley Online Library
Cancer is now considered a tumor microenvironment (TME) disease, although it was
originally thought to be a cell and gene expression disorder. Over the past 20 years …
originally thought to be a cell and gene expression disorder. Over the past 20 years …
[HTML][HTML] CAR T cell therapy for solid tumors: bright future or dark reality?
J Wagner, E Wickman, C DeRenzo, S Gottschalk - Molecular therapy, 2020 - cell.com
Chimeric antigen receptor (CAR) T cell therapy has garnered significant excitement due to
its success for hematological malignancies in clinical studies leading to the US Food and …
its success for hematological malignancies in clinical studies leading to the US Food and …