Droplet microfluidics for high-throughput analysis of antibiotic susceptibility in bacterial cells and populations

W Postek, P Garstecki - Accounts of Chemical Research, 2022 - ACS Publications
Conspectus Antibiotic-resistant bacteria are an increasing concern both in everyday life and
specialized environments such as healthcare. As the rate of antibiotic-resistant infections …

Optimization of the hemolysis assay for the assessment of cytotoxicity

IP Sæbø, M Bjørås, H Franzyk, E Helgesen… - International journal of …, 2023 - mdpi.com
In vitro determination of hemolytic properties is a common and important method for
preliminary evaluation of cytotoxicity of chemicals, drugs, or any blood-contacting medical …

Probing antimicrobial resistance and sanitizer tolerance themes and their implications for the food industry through the Listeria monocytogenes lens

R Bland, SRB Brown, J Waite‐Cusic… - … Reviews in Food …, 2022 - Wiley Online Library
The development of antibiotic resistance is a serious public health crisis, reducing our ability
to effectively combat infectious bacterial diseases. The parallel study of reduced …

[HTML][HTML] Specifically targeted antimicrobial peptides synergize with bacterial-entrapping peptide against systemic MRSA infections

B Xu, L Wang, C Yang, R Yan, P Zhang, M Jin… - Journal of advanced …, 2025 - Elsevier
Introduction The design of precision antimicrobials aims to personalize the treatment of drug-
resistant bacterial infections and avoid host microbiota dysbiosis. Objectives This study …

Artificial intelligence-driven antimicrobial peptide discovery

P Szymczak, E Szczurek - Current Opinion in Structural Biology, 2023 - Elsevier
Antimicrobial peptides (AMPs) emerge as promising agents against antimicrobial resistance,
providing an alternative to conventional antibiotics. Artificial intelligence (AI) revolutionized …

Revealing the mechanisms of synergistic action of two magainin antimicrobial peptides

B Bechinger, DW Juhl, E Glattard… - Frontiers in Medical …, 2020 - frontiersin.org
The study of peptide-lipid and peptide-peptide interactions as well as their topology and
dynamics using biophysical and structural approaches have changed our view how …

Overcoming biological barriers to improve treatment of a Staphylococcus aureus wound infection

V Papadopoulou, AE Sidders, KY Lu, AZ Velez… - Cell chemical …, 2023 - cell.com
Chronic wounds frequently become infected with bacterial biofilms which respond poorly to
antibiotic therapy. Aminoglycoside antibiotics are ineffective at treating deep-seated wound …

How to combat gram-negative bacteria using antimicrobial peptides: a challenge or an unattainable goal?

A Barreto-Santamaría, G Arévalo-Pinzón, MA Patarroyo… - Antibiotics, 2021 - mdpi.com
Antimicrobial peptides (AMPs) represent a promising and effective alternative for combating
pathogens, having some advantages compared to conventional antibiotics. However, AMPs …

Lung antimicrobial proteins and peptides: From host defense to therapeutic strategies

YP Di, JM Kuhn, ML Mangoni - Physiological Reviews, 2024 - journals.physiology.org
Representing severe morbidity and mortality globally, respiratory infections associated with
chronic respiratory diseases, including complicated pneumonia, asthma, interstitial lung …

Perturbation-specific transcriptional mapping for unbiased target elucidation of antibiotics

KP Romano, J Bagnall, T Warrier, J Sullivan… - Proceedings of the …, 2024 - pnas.org
The rising prevalence of antibiotic resistance threatens human health. While more
sophisticated strategies for antibiotic discovery are being developed, target elucidation of …