Proteins are nature's primary building blocks for the construction of sophisticated molecular
machines and dynamic materials, ranging from protein complexes such as photosystem II …

Nature uses a limited, conservative set of amino acids to synthesize proteins. The ability to
genetically encode an expanded set of building blocks with new chemical and physical …

Our understanding of the complex molecular processes of living organisms at the molecular
level is growing exponentially. This knowledge, together with a powerful arsenal of tools for …

The emergence of robust methods to expand the genetic code allows incorporation of non-
canonical amino acids into the polypeptide chain of proteins, thus making it possible to …

The two main strategies for enzyme engineering, directed evolution and rational design,
have found widespread applications in improving the intrinsic activities of proteins. Although …

Proteins are one of the most important and resourceful biomolecules that find applications in
health, industry, medicine, research, and biotechnology. Given its tremendous relevance …

Proteins are versatile natural building blocks with highly complex and multifunctional
architectures, and self-assembled protein structures have been created by the introduction …

Dynamic control over protein function is a central challenge in synthetic biology. To address
this challenge, we describe the development of an integrated computational and …

Highlights•Modular architecture of repeat proteins reduces design complexity.•Idealized self-
compatible units of native families are designed using sequence and structural information …

We report a new computational protein design method for the construction of oligomeric
protein assemblies around metal centers with predefined coordination geometries. We apply …